RGB-1 

RGB-1 selectively binds to and stabilizes RNA G-quadruplex structures, and reduces the expression of the NRAS proto-oncogene in breast cancer cells. RGB-1 can serve as a tool for investigating the cellular functions of RNA G-quadruplex structures and identifying novel mRNA G-quadruplex-forming sequences. RGB-1 is applicable for breast cancer research^[1].

RGB-1 binds specifically to TERRA RNA G-quadruplex with an apparent K_d of 5.9 μM, showing minimal to no binding to DNA G-quadruplex structures^[1].
RGB-1 selectively reduces translation of mRNA containing a TERRA RNA G-quadruplex in its 5' UTR in a cell-free system^[1].
RGB-1 (5-20 μM) dose-dependently reduces NRAS protein expression in MCF-7 cells, without altering NRAS mRNA levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

460.49

C₂₂H₁₂N₄O₄S₂

930455-91-7

Solid

Light yellow to yellow

O=C1C2=C(SC=C2C3=CC=CO3)N=C4N1CC5=NC6=C(C(N5C4)=O)C(C7=CC=CO7)=CS6

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Katsuda Y, et al. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J Am Chem Soc. 2016;138(29):9037-9040.  [Content Brief]