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NRAS Protein, Human (His, solution)

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NRAS protein is a member of the Ras family that binds GDP/GTP and has intrinsic GTPase activity. This property enables NRAS to actively regulate cellular processes by cycling between a GDP-bound inactive state and a GTP-bound active state. NRAS Protein, Human (His, solution) is the recombinant human-derived NRAS protein, expressed by E. coli , with N-His labeled tag.

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  • Species: Human
  • Source: E. coli
  • NRAS Protein, Human (His, solution) Product Image
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Biological Activity

Description

NRAS protein is a member of the Ras family that binds GDP/GTP and has intrinsic GTPase activity. This property enables NRAS to actively regulate cellular processes by cycling between a GDP-bound inactive state and a GTP-bound active state. NRAS Protein, Human (His, solution) is the recombinant human-derived NRAS protein, expressed by E. coli , with N-His labeled tag.

Background

NRAS, a member of the Ras protein family, is characterized by its ability to bind GDP/GTP and possess intrinsic GTPase activity. This inherent property allows NRAS to actively participate in cellular processes by regulating the cycling between GDP-bound inactive and GTP-bound active states. The dynamic interplay of NRAS with guanine nucleotides underscores its role as a molecular switch, influencing downstream signaling pathways and cellular responses. As a key component in signal transduction cascades, NRAS contributes to the intricate regulation of cellular functions and plays a crucial role in various physiological and pathological processes.

Technical Parameters

  • Species Human
  • Source E. coli
  • Tag N-His
  • Accession

    P01111 (M1-C186)

  • Gene ID
    4893  [NCBI]
  • Molecular Construction
    • N-term
    • His
    • NRAS (M1-C186)
      Accession # P01111
    • C-term
  • Protein Length

    Full Length of Mature Protein

  • Synonyms

    NRAS; Proto-Oncogene GTPase; NRAS Proto-Oncogene, GTPase; N-Ras Protein Part 4; N-Ras; ALPS4; Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog; NRAS1; Neuroblastoma RAS Viral Oncogene Homolog; HRAS1; Transforming Protein N-Ras; CMNS; GTPase NRas; NCMS; V-

  • AA Sequence

    MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPC

  • Predicted Molecular Mass

    23 kDa

  • Molecular Weight

    Approximately 24 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Calculators

Reconstitution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

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MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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  • NRAS Protein, Human (His, solution) Product Image