1. GPCR/G Protein
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  3. MRTX-EX185 formic

MRTX-EX185 formic 

Cat. No.: HY-145962A
Handling Instructions

MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS.

For research use only. We do not sell to patients.

MRTX-EX185 formic Chemical Structure

MRTX-EX185 formic Chemical Structure

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Description

MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS[1].

IC50 & Target

KRas G12D

90 nM (IC50)

Molecular Weight

610.68

Formula

C34H35FN6O4

SMILES

OC1=CC(C2=C(F)C3=NC(OCC45CCCN4CCC5)=NC(N6C[[email protected]@](N7)([H])CC[[email protected]@]7([H])C6)=C3C=N2)=C8C(C#C)=CC=CC8=C1.O=CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (204.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6375 mL 8.1876 mL 16.3752 mL
5 mM 0.3275 mL 1.6375 mL 3.2750 mL
10 mM 0.1638 mL 0.8188 mL 1.6375 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.41 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References
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Product Name:
MRTX-EX185 formic
Cat. No.:
HY-145962A
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