1. GPCR/G Protein
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  3. K-Ras G12C-IN-4

K-Ras G12C-IN-4 

Cat. No.: HY-128771 Purity: 98.60%
Handling Instructions

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.

For research use only. We do not sell to patients.

K-Ras G12C-IN-4 Chemical Structure

K-Ras G12C-IN-4 Chemical Structure

CAS No. : 2376328-55-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 555 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 555 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 745 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1525 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].

In Vitro

K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1].
K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

561.07

Formula

C31H33ClN4O4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (111.39 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7823 mL 8.9115 mL 17.8231 mL
5 mM 0.3565 mL 1.7823 mL 3.5646 mL
10 mM 0.1782 mL 0.8912 mL 1.7823 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.71 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
K-Ras G12C-IN-4
Cat. No.:
HY-128771
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