1. GPCR/G Protein
  2. Ras
  3. K-Ras G12C-IN-4

K-Ras G12C-IN-4 

Cat. No.: HY-128771
Handling Instructions

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.

For research use only. We do not sell to patients.

K-Ras G12C-IN-4 Chemical Structure

K-Ras G12C-IN-4 Chemical Structure

CAS No. : 2376328-55-9

Size Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].

In Vitro

K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1].
K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].

Molecular Weight

561.07

Formula

C₃₁H₃₃ClN₄O₄

CAS No.

2376328-55-9

SMILES

O=C(NC1CN(C(C=C)=O)C1)CN2C(C3CC3)=C(C(N4CC5=C(C(OC)=CC=C5)CC4)=O)C6=C2C(C)=CC(Cl)=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

K-Ras G12C-IN-4RasInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
K-Ras G12C-IN-4
Cat. No.:
HY-128771
Quantity:
MCE Japan Authorized Agent: