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Cat. No.: HY-164350

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KRAS inhibitor-27

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC₅₀ of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC₅₀ in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway.

For research use only. We do not sell to patients.

CAS No.: 3033690-83-1
Formula: C₃₁H₂₈ClF₃N₆O₃S
Molecular Weight:657.11

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

KRAS inhibitor-27 Chemical Structure

CAS No.: 3033690-83-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Ras Isoforms :

All ERK Isoforms :

All p38 MAPK Isoforms :

Chemical Information

CAS No. 3033690-83-1
Appearance Solid
Molecular Weight 657.11
Formula C₃₁H₂₈ClF₃N₆O₃S
SMILES

F[C@@H]1C[C@]2(COC3=NC4=C5C(OC[C@@]6(COCCCN64)[H])=C(Cl)[C@]([C@](C=CC(F)=C7S8)=C7C(C#N)=C8N)=C(F)C5=N3)CCCN2C1
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Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Naunyn Schmiedebergs Arch Pharmacol

Integrated multi-omics and experimental validation for identifying novel biomarkers of acute myocardial infarction. [Abstract]

2026 Jun;399(9):14067-14089. PMID: 41949600

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hong C, et al. Discovery of novel tetracyclic quinazolines as multi-KRASáinhibitors for the treatment of solid tumors[J]. Bioorganic & Medicinal Chemistry Letters, 2025, 118: 130087.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KRAS inhibitor-27

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
Purity & Documentation
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KRAS inhibitor-27

Publications Citing Use of MedChemExpress (MCE) KRAS inhibitor-27

All Ras Isoforms

All ERK Isoforms

All p38 MAPK Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

KRAS inhibitor-27 Related Classifications

HY-164350 Related Classifications