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Cat. No.: HY-152248

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ARS-2102

ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2098509-21-6
Formula: C₂₈H₃₁ClF₂N₆O₂
Molecular Weight:557.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ARS-2102 Chemical Structure

CAS No.: 2098509-21-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research^[1].

All Ras Isoforms :

Chemical Information

CAS No. 2098509-21-6
Molecular Weight 557.03
Formula C₂₈H₃₁ClF₂N₆O₂
SMILES

FC1=C(C2=C(C=CC=C2O)F)C(Cl)=CC3=C1N=C(N4CC(C4)N(C)C)N=C3N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiaogen Yang, et al. Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102.Org. Process Res. Dev. 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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