KRAS G12D-IN-36
KRAS G12D-IN-36 (Compound 53a) is a highly selective and orally active KRAS-G12D inhibitor with an IC50 of 1.63 nM. KRAS G12D-IN-36 effectively inhibits p-ERK with an IC50 of 8.4 nM. KRAS G12D-IN-36 shows potent anti-proliferative activity against AsPC-1 cells. KRAS G12D-IN-36 can be used for research on pancreatic cancer.
For research use only. We do not sell to patients.
- Formula: C40H42F3N7O3
- Molecular Weight:725.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12D 1.63 nM (IC50) |
Chemical Information
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Molecular Weight 725.80
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Formula C40H42F3N7O3
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SMILES
FC(C1=C(C(N2[C@@H]3CN(C[C@H]2CC3)CCCOC)=NC(OC[C@]45C[C@H](CN4CCC5)F)=N1)C6=CN(N=C76)C)=C7C8=C9C(C#C)=C(F)C=CC9=CC(O)=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS G12D-IN-36 Related Classifications
HY-180920 Related Classifications
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