Cat. No.: HY-18707

K-Ras(G12C) inhibitor 12

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

K-Ras(G12C) inhibitor 12 is an irreversible inhibitor of K-Ras(G12C). K-Ras(G12C) inhibitor 12 can alter the nucleotide-binding preference of K-Ras and block its interaction with effector proteins. K-Ras(G12C) inhibitor 12 can reduce cell viability and induce apoptosis in lung cancer cell lines with G12C mutations. K-Ras(G12C) inhibitor 12 has anti-tumor activity.

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Purity: 99.57%
CAS No.: 1469337-95-8
화학식: C₁₅H₁₇ClIN₃O₃
분자량:449.67

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

K-Ras(G12C) inhibitor 12 Chemical Structure

CAS No.: 1469337-95-8

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
Publications (1)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Ras Isoforms :

In Vitro

K-Ras(G12C) inhibitor 12 (Compound 12) (0.01-10 μM; 48-72 h) can inhibit cell viability and increase apoptosis in lung cancer cell lines with K-Ras (G12C) mutations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

H1792, H358, Calu-1, H23, A549, H1299 and H1437 cells
Concentration:

0.01, 0.05, 0.1, 0.5, 1, 5 and 10 μM
Incubation Time:

72 h
Result:

Inhibited the cell viability of K-Ras(G12C)-mutant cell lines (H1792, H358, Calu-1 and H23) and did not affect cell viability of cell lines lacking this mutation (A549, H1299 and H1437).

Chemical Information

CAS No. 1469337-95-8
Appearance Solid
분자량 449.67
화학식 C₁₅H₁₇ClIN₃O₃
Color White to light yellow
SMILES

C=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

bioRxiv

2026 May 7.

용액&용해도

In Vitro:

DMSO : 100 mg/mL (222.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2239 mL

11.1193 mL

22.2385 mL

5 mM

0.4448 mL

2.2239 mL

4.4477 mL

10 mM

0.2224 mL

1.1119 mL

2.2239 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.67 mg/mL (3.71 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.67 mg/mL (3.71 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-551. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2239 mL	11.1193 mL	22.2385 mL	55.5963 mL
	5 mM	0.4448 mL	2.2239 mL	4.4477 mL	11.1193 mL
	10 mM	0.2224 mL	1.1119 mL	2.2239 mL	5.5596 mL
	15 mM	0.1483 mL	0.7413 mL	1.4826 mL	3.7064 mL
	20 mM	0.1112 mL	0.5560 mL	1.1119 mL	2.7798 mL
	25 mM	0.0890 mL	0.4448 mL	0.8895 mL	2.2239 mL
	30 mM	0.0741 mL	0.3706 mL	0.7413 mL	1.8532 mL
	40 mM	0.0556 mL	0.2780 mL	0.5560 mL	1.3899 mL
	50 mM	0.0445 mL	0.2224 mL	0.4448 mL	1.1119 mL
	60 mM	0.0371 mL	0.1853 mL	0.3706 mL	0.9266 mL
	80 mM	0.0278 mL	0.1390 mL	0.2780 mL	0.6950 mL
	100 mM	0.0222 mL	0.1112 mL	0.2224 mL	0.5560 mL

Keywords

K-Ras(G12C) inhibitor 12

1 Cited Publications

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K-Ras(G12C) inhibitor 12

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Publications Citing Use of MedChemExpress (MCE) K-Ras(G12C) inhibitor 12

All Ras Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

K-Ras(G12C) inhibitor 12 Related Classifications

HY-18707 Related Classifications