G-quadruplex ligand 4
G-quadruplex ligand 4 is a chromenone derivative and is a human telomerase reverse transcriptase (hTERT) G4 ligand. G-quadruplex ligand 4 downregulates hTERT expression and exhibits notable cytotoxicity towards triple-negative breast cancer (TNBC) cell lines. G-quadruplex ligand 4 can cause S/G2 cell cycle arrest and induce apoptosis. G-quadruplex ligand 4 downregulates the expression of hTERT, KRAS, and BCL-2. G-quadruplex ligand 4 can be used for the research of TNBC.
For research use only. We do not sell to patients.
- Formula: C25H30N4O2
- Molecular Weight:418.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Bcl-2 |
K-RAS |
G-quadruplex ligand 4 (Compound 17) (72 h) inhibits cell viability in MDA-MB-231, HCC-1806, MCF-7 and HEK-293 with IC50 values of 2.5, 2.7 , 5.5 and 3.3 μM[1].
G-quadruplex ligand 4 (2.5-10 μM; 72 h) causes G2/S phase cell cycle arrest and induces apoptosis in MDA-MB-231 cells[1].
G-quadruplex ligand 4 (2.5-10 μM; 24 h) downregulates the expression of hTERT, KRAS, and BCL-2 in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:2.5 μM, 5 μM, 10 μM
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Incubation Time:72 h
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Result:Showed increasing proportions of early-apoptotic (4.9%, 9.5%, 28.8%) and late-apoptotic cells (12.1%, 17.4%, 30.0%) at different concentrations.
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Cell Line:MDA-MB-231 cells
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Concentration:2.5 μM, 5 μM, 10 μM
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Incubation Time:72 h
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Result:Increased the proportion of cells in the S phase (17.5%, 23.9%, 29.0%) and G2 phase (11.1%, 16.1%, 23.7%).
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Cell Line:MDA-MB-231 cells
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Concentration:2.5 μM, 5 μM, 10 μM
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Incubation Time:24 h
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Result:Showed significant reductions in mRNA levels with KRAS (21-23 %), BCL-2 (25-30 %), and hTERT (40-56 %); \r
whereas the expression of HRAS and c-MYC remained unchanged.
Chemical Information
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Molecular Weight 418.53
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Formula C25H30N4O2
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SMILES
CN1CCN(CC1)C2=CC=C(C=C2)C3=CC(C4=C(O3)C=CC(N5CCN(CC5)C)=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G-quadruplex ligand 4 Related Classifications
HY-179480 Related Classifications
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