2. Others Cell Cycle/DNA Damage Apoptosis MAPK/ERK Pathway GPCR/G Protein
  3. Drug Derivative G-quadruplex Apoptosis Telomerase Ras Bcl-2 Family
  4. G-quadruplex ligand 4

G-quadruplex ligand 4 is a chromenone derivative and is a human telomerase reverse transcriptase (hTERT) G4 ligand. G-quadruplex ligand 4 downregulates hTERT expression and exhibits notable cytotoxicity towards triple-negative breast cancer (TNBC) cell lines. G-quadruplex ligand 4 can cause S/G2 cell cycle arrest and induce apoptosis. G-quadruplex ligand 4 downregulates the expression of hTERT, KRAS, and BCL-2. G-quadruplex ligand 4 can be used for the research of TNBC.

For research use only. We do not sell to patients.

G-quadruplex ligand 4

G-quadruplex ligand 4 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

G-quadruplex ligand 4 Related Antibodies

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras N-Ras Ras

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

G-quadruplex ligand 4 is a chromenone derivative and is a human telomerase reverse transcriptase (hTERT) G4 ligand. G-quadruplex ligand 4 downregulates hTERT expression and exhibits notable cytotoxicity towards triple-negative breast cancer (TNBC) cell lines. G-quadruplex ligand 4 can cause S/G2 cell cycle arrest and induce apoptosis. G-quadruplex ligand 4 downregulates the expression of hTERT, KRAS, and BCL-2. G-quadruplex ligand 4 can be used for the research of TNBC[1].

IC50 & Target[1]

Bcl-2

 

K-RAS

 

In Vitro

G-quadruplex ligand 4 (Compound 17) (72 h) inhibits cell viability in MDA-MB-231, HCC-1806, MCF-7 and HEK-293 with IC50 values of 2.5, 2.7 , 5.5 and 3.3 μM[1].
G-quadruplex ligand 4 (2.5-10 μM; 72 h) causes G2/S phase cell cycle arrest and induces apoptosis in MDA-MB-231 cells[1].
G-quadruplex ligand 4 (2.5-10 μM; 24 h) downregulates the expression of hTERT, KRAS, and BCL-2 in MDA-MB-231 cells[1]. 

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

G-quadruplex ligand 4 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5 μM, 5 μM, 10 μM
Incubation Time: 72 h
Result: Showed increasing proportions of early-apoptotic (4.9%, 9.5%, 28.8%) and late-apoptotic cells (12.1%, 17.4%, 30.0%) at different concentrations.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration:  2.5 μM, 5 μM, 10 μM
Incubation Time: 72 h
Result: Increased the proportion of cells in the S phase (17.5%, 23.9%, 29.0%) and G2 phase (11.1%, 16.1%, 23.7%). 

Real Time qPCR[1]

Cell Line: MDA-MB-231 cells
Concentration:  2.5 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Showed significant reductions in mRNA levels with KRAS (21-23 %), BCL-2 (25-30 %), and hTERT (40-56 %); \r
whereas the expression of HRAS and c-MYC remained unchanged.
Molecular Weight

418.53

Formula

C25H30N4O2
SMILES

CN1CCN(CC1)C2=CC=C(C=C2)C3=CC(C4=C(O3)C=CC(N5CCN(CC5)C)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

G-quadruplex ligand 4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G-quadruplex ligand 4Drug DerivativeG-quadruplexApoptosisTelomeraseRasBcl-2 FamilyDrug derivativehTERTTNBCMDA-MB-231HCC-1806MCF-7HEK-293Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
G-quadruplex ligand 4
Cat. No.:
HY-179480
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.