2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. AUBE00

AUBE00 is an orally active, selective cyclic peptide pan-KRAS inhibitor. AUBE00 selectively binds to the OFF state of KRAS. AUBE00 exhibits anticancer activity against RAS wild-type colorectal cancer. The combination of AUBE00 with Cetuximab (HY-P9905) produces a synergistic antiproliferative effect.

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AUBE00

AUBE00 Chemical Structure

CAS No. : 2874214-01-2

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AUBE00 Related Antibodies

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Description

AUBE00 is an orally active, selective cyclic peptide pan-KRAS inhibitor. AUBE00 selectively binds to the OFF state of KRAS. AUBE00 exhibits anticancer activity against RAS wild-type colorectal cancer. The combination of AUBE00 with Cetuximab (HY-P9905) produces a synergistic antiproliferative effect[1].

IC50 & Target[1]

K-RAS

 

In Vitro

AUBE00 exhibits potent antiproliferative activity against cancer cell lines harboring various KRAS mutations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AUBE00 Related Antibodies
Molecular Weight

1553.77

Formula

C78H110F6N12O14
CAS No.
SMILES

CN1C2(CCC2)C(N([C@@H](C3CCCC3)C(N([C@@H](CC(N([C@H](C(N[C@@](C(N4[C@](CCC4)([H])C(N([C@]5([H])C(N(CC/C=C\C5)[C@H](C(N(CC(N[C@H](C(N6[C@](C[C@H](C6)OCC)([H])C1=O)=O)CCC7=CC(OC)=C(C=C7)C(F)(F)F)=O)C)=O)CC8=CC=C(C=C8)C(F)(F)F)=O)C)=O)=O)([H])[C@@H](C)CC)=O)CCC)C)=O)C(N(C)C)=O)C)=O)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AUBE00 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AUBE002874214-01-2AUBE 00AUBE-00RasRAS wild-type colorectal cancer modelsKRAS-mutant cancerspreclinical modelscancer cellsKRAS (OFF state)advanced solid tumorscetuximabKRAS G13D mutationsKRAS wild-type amplificationKRAS alterationsInhibitorinhibitorinhibit

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