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  3. K-Ras G12C-IN-3

K-Ras G12C-IN-3 

Cat. No.: HY-18606 Purity: 99.92%
Handling Instructions

K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

For research use only. We do not sell to patients.

K-Ras G12C-IN-3 Chemical Structure

K-Ras G12C-IN-3 Chemical Structure

CAS No. : 1629268-19-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 419 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. IC50 value: Target: K-ras G12C inhibitor For more information, please see the following patent. Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereof By Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.

Molecular Weight

453.75

Formula

C₂₁H₁₉Cl₃N₂O₃

CAS No.

1629268-19-4

SMILES

ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (66.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2039 mL 11.0193 mL 22.0386 mL
5 mM 0.4408 mL 2.2039 mL 4.4077 mL
10 mM 0.2204 mL 1.1019 mL 2.2039 mL
*Please refer to the solubility information to select the appropriate solvent.

Purity: 99.92%

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Keywords:

K-Ras G12C-IN-3RasInhibitorinhibitorinhibit

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Product Name:
K-Ras G12C-IN-3
Cat. No.:
HY-18606
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