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Cat. No.: HY-189349

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KRAS ligand-7

KRAS ligand-7 is a ligand for KRAS and can be used in research related to PROTAC synthesis. KRAS ligand-7 can serve as the target protein ligand for CW-10201 (HY-189305).

For research use only. We do not sell to patients.

Formula: C₂₆H₂₄F₂N₄O₃
Molecular Weight:478.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS ligand-7 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

KRAS ligand-7 is a ligand for KRAS and can be used in research related to PROTAC synthesis. KRAS ligand-7 can serve as the target protein ligand for CW-10201 (HY-189305)^[1].

IC₅₀ & Target

^[1]

KRas G12D

KRas G12V

All Ras Isoforms :

In Vitro

KRAS ligand-7 can serve as the target protein ligand for CW-10201 (HY-189305). CW-10201 is a KRAS^G12D and KRAS^G12V PROTAC degrader with DC₅₀ values of 4.0 nM. CW-10201 exhibits anticancer activity against pancreatic cancer and colorectal cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

Molecular Weight 478.49
Formula C₂₆H₂₄F₂N₄O₃
SMILES

OC1=NC(N(CCC2)C[C@]32CCO3)=C(C=NC(C4=C5C(CC)=C(F)C=CC5=CC(O)=C4)=C6F)C6=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations. Journal of medicinal chemistry. 2026 Sep 10;69(17):20520-20539.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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KRAS ligand-7

All Ras Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS ligand-7 Related Classifications

HY-189349 Related Classifications

Bioz

Keywords

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