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Cat. No.: HY-156528

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pan-KRAS-IN-4

pan-KRAS-IN-4 (compound 5) is a potent inhibitor of KRAS with IC₅₀s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively.

For research use only. We do not sell to patients.

CAS No.: 2885961-55-5
Formula: C₃₆H₃₄F₂N₆O₃
Molecular Weight:636.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

pan-KRAS-IN-4 Chemical Structure

CAS No.: 2885961-55-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

pan-KRAS-IN-4 (compound 5) is a potent inhibitor of KRAS with IC₅₀s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively^[1].

IC₅₀ & Target

IC50: 0.37 nM (Kras G12C), 0.19 nM (Kras G12V)

All Ras Isoforms :

Chemical Information

CAS No. 2885961-55-5
Molecular Weight 636.69
Formula C₃₆H₃₄F₂N₆O₃
SMILES

C=CC(N1[C@@]2([H])CN(C3=C(C=NC(C4=C5C(C#C)=C(F)C=CC5=CC(O)=C4)=C6F)C6=NC(OCC78CCCN7CCC8)=N3)C[C@]1([H])CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. Synthesis of Mutant KRAS modulators treating neoplastic, autoimmune diseases, and inflammatory disorders. World Intellectual Property Organization, WO2022271823 A1 2022-12-29.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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pan-KRAS-IN-4

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

pan-KRAS-IN-4 Related Classifications

HY-156528 Related Classifications