2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. RMC-9805

RMC-9805  (Synonyms: KRAS G12D inhibitor 18)

Cat. No.: HY-156819 Purity: 98.90%
COA Handling Instructions

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RMC-9805 (KRAS G12D inhibitor 18) is a KRAS G12D inhibitor. RMC-9805 is orally active. RMC-9805 inhibits RAS signaling and induces apoptosis in KRAS G12D mutant cancer cells.

For research use only. We do not sell to patients.

RMC-9805 Chemical Structure

RMC-9805 Chemical Structure

CAS No. : 2922732-54-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 874 In-stock
Solution
10 mM * 1 mL in DMSO USD 874 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1550 In-stock
50 mg USD 2550 In-stock
100 mg USD 4100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

RMC-9805 (KRAS G12D inhibitor 18) is a KRAS G12D inhibitor[1]. RMC-9805 is orally active. RMC-9805 inhibits RAS signaling and induces apoptosis in KRAS G12D mutant cancer cells[2].

IC50 & Target[1]

KRAS(G12D)

 

Molecular Weight

1168.44

Formula

C63H88F3N11O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1NN(C([C@@H](NC([C@@H](N2C[C@]3(CN(C([C@@H]4N(C)[C@@H]4C5CC5)=O)CC3)CC2)C6CCCC6)=O)C[C@H]7CN8CCO7)=O)CCC1)OCC(C)(C)CC9=[C@@]([C@@]%10=C([C@@H](OC)C)N=CC(N%11CCN(C%12CC%12)CC%11)=C%10)N(CC(F)(F)F)C%13=C9C=C8C=C%13
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (106.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8558 mL 4.2792 mL 8.5584 mL
5 mM 0.1712 mL 0.8558 mL 1.7117 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73%

COA (252 KB) HNMR (359 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8558 mL 4.2792 mL 8.5584 mL 21.3961 mL
5 mM 0.1712 mL 0.8558 mL 1.7117 mL 4.2792 mL
10 mM 0.0856 mL 0.4279 mL 0.8558 mL 2.1396 mL
15 mM 0.0571 mL 0.2853 mL 0.5706 mL 1.4264 mL
20 mM 0.0428 mL 0.2140 mL 0.4279 mL 1.0698 mL
25 mM 0.0342 mL 0.1712 mL 0.3423 mL 0.8558 mL
30 mM 0.0285 mL 0.1426 mL 0.2853 mL 0.7132 mL
40 mM 0.0214 mL 0.1070 mL 0.2140 mL 0.5349 mL
50 mM 0.0171 mL 0.0856 mL 0.1712 mL 0.4279 mL
60 mM 0.0143 mL 0.0713 mL 0.1426 mL 0.3566 mL
80 mM 0.0107 mL 0.0535 mL 0.1070 mL 0.2675 mL
100 mM 0.0086 mL 0.0428 mL 0.0856 mL 0.2140 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RMC-98052922732-54-3KRAS G12D inhibitor 18RMC9805RMC 9805RasKRAS G12D InhibitorInhibitorinhibitorinhibit

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