1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokines
  5. CCL17

CCL17, also known as thymic and activating regulatory chemokine (TARC), is a powerful chemokine commonly associated with type 2 immune responses, and its encoding gene is located on chromosome 16 in humans. CCL17 can be produced by thymic and antigen-presenting cells such as dendritic cells, macrophages, and monocytes, and acts by binding to the cell surface chemokine receptor CCR4. CCR4 is a G protein-coupled receptor expressed as a chemokine receptor on Th2 cells, cutaneous lymphocytes skin-localized T cells and regulatory T cells, and also on T cells in adult T-cell leukemia/lymphoma and cutaneous T-cell lymphoma. CCR4 has an important role in the regulation of immune homeostasis and activation of innate immune cells in the central nervous system (CNS). CCL17 plays an important role in the recruitment of CCR4-positive Th2 lymphocytes, is involved in the transport of Th2 cells in eosinophil-associated diseases (including AA and AD) and may be involved in the transport of tumor cells in certain T-cell lymphomas.CCL17 is also thought to be a homeostatic and inducible neuromodulatory chemokine that maintains the typical highly branching morphology of hippocampal microglia under homeostatic conditions and promotes adaptation of microglia morphology to acute LPS-induced neuroinflammation. CCL17 is also associated with autoimmune and allergic disorders[1][2].

Cat. No. Product Name / Synonyms Species Source
  • HY-P7292
    TARC/CCL17 Protein, Human

    rHuTARC/CCL17; C-C motif chemokine 17; SCYA17

    Human E. coli
    TARC/CCL17 Protein, Human is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Human is a recombinant human TARC/CCL17 (A24-S94) protein expressed by E. coli.
  • HY-P74532
    TARC/CCL17 Protein, Human (sf9)

    C-C motif chemokine 17; CCL17; SCYA17; TARC

    Human Sf9 insect cells
    TARC/CCL17 Protein, Human (sf9) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Human (sf9) is a recombinant human TARC/CCL17(M1-S94) protein expressed by Sf9 insect cells.
  • HY-P7759
    TARC/CCL17 Protein, Human (HEK293, His)

    rHuCCL17, His; C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; SCYA17; TARC

    Human HEK293
    TARC/CCL17 Protein, Human (HEK293, His) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Human (HEK293, His) is a recombinant human TARC/CCL17(A24-S94) protein expressed by HEK293 with a his tag at C end.
  • HY-P71891A
    TARC/CCL17 Protein, Mouse (His)

    C-C motif chemokine; CCL17

    Mouse E. coli
    The TARC/CCL17 protein selectively attracts T lymphocytes, especially Th2 cells, emphasizing its critical role in inflammation and immunity. TARC/CCL17 binds to CCR4 on the surface of T cells, orchestrates immune responses, and contributes to GM-CSF/CSF2-driven pain and inflammation. TARC/CCL17 Protein, Mouse (His) is the recombinant mouse-derived TARC/CCL17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TARC/CCL17 Protein, Mouse (His) is 70 a.a., with molecular weight of ~10 kDa.
  • HY-P71902
    CCL17 Protein, Rat

    C-C motif chemokine; CCL17

    Rat E. coli
    CCL17 protein is a chemokine with selective chemotactic activity towards Th2 cells and plays a crucial role in various inflammatory and immune processes. It coordinates immune responses by binding to CCR4 on the surface of T cells. CCL17 Protein, Rat is the recombinant rat-derived CCL17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CCL17 Protein, Rat is 70 a.a., with molecular weight of ~12 kDa.
  • HY-P7293
    TARC/CCL17 Protein, Mouse (70a.a)

    rMuTARC/CCL17; C-C motif chemokine 17; SCYA17

    Mouse E. coli
    TARC/CCL17 Protein, Mouse (70a.a) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Mouse (70a.a) is a recombinant mouse TARC/CCL17(A34-P103) protein expressed by E. coli.
  • HY-P74531
    TARC/CCL17 Protein, Human (sf9, His)

    C-C motif chemokine 17; CCL17; SCYA17; TARC

    Human Sf9 insect cells
    TARC/CCL17 Protein, Human (sf9, His) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Human (sf9, His) is a recombinant human TARC/CCL17(M1-S94) protein expressed by Sf9 insect cells with a his tag at C end.
  • HY-P76667
    TARC/CCL17 Protein, Rhesus Macaque (sf9, His)

    C-C motif chemokine 17; CCL17; SCYA17; TARC

    Rhesus Macaque Sf9 insect cells
    TARC/CCL17 Protein,Rhesus Macaque (sf9, His) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein,Rhesus Macaque (sf9, His) is a recombinant rhesus macaque TARC/CCL17(M1-S94) protein expressed by Sf9 insect cells with a his tag at C end.
  • HY-P700552
    TARC/CCL17 Protein, Dog (HEK293, His)

    rHuTARC/CCL17; C-C motif chemokine 17; SCYA17

    Dog HEK293
    The TARC/CCL17 protein attracts T lymphocytes, particularly Th2 cells, and is involved in inflammation and immunity. It binds to CCR4 on T cells and contributes to GM-CSF/CSF2-induced pain and inflammation. In the brain, it maintains hippocampal microglia morphology and aids in adapting to neuroinflammation. Additionally, it plays a role in wound healing by promoting fibroblast migration. TARC/CCL17 Protein, Dog (HEK293, His) is the recombinant dog-derived TARC/CCL17 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TARC/CCL17 Protein, Dog (HEK293, His) is 76 a.a., with molecular weight of 10.8 kDa.
Cat. No. Product Name Effect Purity