MM41
Based on 1 Customer Validation
MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer.
For research use only. We do not sell to patients.
- Purity: 98.89%
- CAS No.: 1429028-96-5
- Formula: C44H66N10O6
- Molecular Weight:831.06
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
More
Biological Activity
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Caspase 3 |
Bcl-2 |
K-RAS |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | IC50 |
0.32 μM
Compound: 3d
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Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 23514618] |
| A549 | IC50 |
<0.01 μM
Compound: 3d
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Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay
|
[PMID: 23514618] |
| A549 | IC50 |
19 nM
Compound: MM41
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Growth inhibition of human A549 cells after 96 hrs by SRB assay
Growth inhibition of human A549 cells after 96 hrs by SRB assay
|
[PMID: 29356532] |
| MCF7 | IC50 |
0.07 μM
Compound: 3d
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 23514618] |
| MCF7 | IC50 |
70 nM
Compound: MM41
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Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| MIA PaCa-2 | IC50 |
0.01 μM
Compound: 3d
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Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 23514618] |
| MIA PaCa-2 | IC50 |
11 nM
Compound: MM41
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Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| PANC-1 | IC50 |
0.003 μM
Compound: 2a
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Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay
Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay
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[PMID: 23769166] |
| PANC-1 | IC50 |
3 nM
Compound: MM41
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Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| RCC4 | IC50 |
0.56 μM
Compound: 3d
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Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 23514618] |
| WI-38 | IC50 |
0.23 μM
Compound: 3d
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Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 23514618] |
| WI-38 | IC50 |
230 nM
Compound: MM41
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Growth inhibition of human WI38 cells after 96 hrs by SRB assay
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
MM41 (1 μM) stabilizes the BCL-2 promoter G-quadruplex with a ΔTₘ value of 26.4 °C, and also binds effectively to k-RAS1 and k-RAS2 promoter G-quadruplexes with ΔTₘ values of 22.5 °C and 19.8 °C respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 nude mice (2-3 months old, weighing 20-25 g) bearing MIA PaCa-2 pancreatic cancer subcutaneous xenografts[1]
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Dosage:10 mg/kg, 15 mg/kg
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Administration:Intravenous administration, twice weekly, 12 doses
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Result:Resulted in an average reduction of ca 80% in tumor growth by day 40 in mice, cessation of tumor regrowth from day 30 onwards, and complete tumor regression in two mice with no regrowth for 239 days (15 mg/kg).
Showed weaker anti-tumour effect (10 mg/kg).
Showed reduced BCL-2 and k-RAS protein levels in treated tumours.
Showed that treated tumours, but not untreated ones, show high levels of caspase 3 staining.
Chemical Information
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CAS No. 1429028-96-5
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Appearance Solid
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Molecular Weight 831.06
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Formula C44H66N10O6
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Color Blue to purple
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SMILES
O=C1C2=CC(NCCCN3CCN(CC3)C)=C4C(N(CCCN5CCOCC5)C(C6=CC(NCCCN7CCN(CC7)C)=C(C2=C64)C(N1CCCN8CCOCC8)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
1 M HCl : 100 mg/mL (120.33 mM; Need ultrasonic)
DMSO : 33.33 mg/mL (40.11 mM; ultrasonic and adjust pH to 8 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1 M HCl | 1 mM | 1.2033 mL | 6.0164 mL | 12.0328 mL | 30.0821 mL |
| 5 mM | 0.2407 mL | 1.2033 mL | 2.4066 mL | 6.0164 mL | |
| 10 mM | 0.1203 mL | 0.6016 mL | 1.2033 mL | 3.0082 mL | |
| 15 mM | 0.0802 mL | 0.4011 mL | 0.8022 mL | 2.0055 mL | |
| 20 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.5041 mL | |
| 25 mM | 0.0481 mL | 0.2407 mL | 0.4813 mL | 1.2033 mL | |
| 30 mM | 0.0401 mL | 0.2005 mL | 0.4011 mL | 1.0027 mL | |
| 40 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.7521 mL | |
| 1 M HCl | 50 mM | 0.0241 mL | 0.1203 mL | 0.2407 mL | 0.6016 mL |
| 60 mM | 0.0201 mL | 0.1003 mL | 0.2005 mL | 0.5014 mL | |
| 80 mM | 0.0150 mL | 0.0752 mL | 0.1504 mL | 0.3760 mL | |
| 100 mM | 0.0120 mL | 0.0602 mL | 0.1203 mL | 0.3008 mL |
MM41 Related Classifications
HY-16967 Related Classifications
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