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Cat. No.: HY-48187

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KRAS inhibitor-39

Customer Review

Based on 1 Customer Validation

KRAS inhibitor-39 (Example 46) is an intermediate of BI-0474 (HY-148278). BI-0474 is a robust KRAS^G12C inhibitor.

For research use only. We do not sell to patients.

Purity: 98.36%
CAS No.: 3034744-25-4
Formula: C₂₇H₃₅N₉OS
Molecular Weight:533.69

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

KRAS inhibitor-39 Chemical Structure

CAS No.: 3034744-25-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

KRAS inhibitor-39 (Example 46) is an intermediate of BI-0474 (HY-148278). BI-0474 is a robust KRAS^G12C inhibitor^[1].

Chemical Information

CAS No. 3034744-25-4
Appearance Solid
Molecular Weight 533.69
Formula C₂₇H₃₅N₉OS
Color White to off-white
SMILES

N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(N5[C@@H](C)CN(C)CC5)=CC(N6CCNCC6)=C4)=NO3)CCC2
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bröker, et al. Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor. Journal of medicinal chemistry. 2022, 65(21):14614-14629. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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