2. PROTAC PI3K/Akt/mTOR
  3. PROTACs PDK-1 Akt
  4. SMART1

SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) .

For research use only. We do not sell to patients.

SMART1

SMART1 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SMART1 Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) [1].
Molecular Weight

753.76

Formula

C40H35N9O7
Appearance

Solid

Color

Light yellow to green yellow

SMILES

CNC(C1=NC=CC(OC2=CC=C(C=C2)N3C=C(N=N3)C4=CC(NC(C5CCCN(C5)C6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CC=C4)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (132.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3267 mL 6.6334 mL 13.2668 mL
5 mM 0.2653 mL 1.3267 mL 2.6534 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

SDS (393 KB)

COA (244 KB) HNMR (466 KB) RP-HPLC (239 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3267 mL 6.6334 mL 13.2668 mL 33.1671 mL
5 mM 0.2653 mL 1.3267 mL 2.6534 mL 6.6334 mL
10 mM 0.1327 mL 0.6633 mL 1.3267 mL 3.3167 mL
15 mM 0.0884 mL 0.4422 mL 0.8845 mL 2.2111 mL
20 mM 0.0663 mL 0.3317 mL 0.6633 mL 1.6584 mL
25 mM 0.0531 mL 0.2653 mL 0.5307 mL 1.3267 mL
30 mM 0.0442 mL 0.2211 mL 0.4422 mL 1.1056 mL
40 mM 0.0332 mL 0.1658 mL 0.3317 mL 0.8292 mL
50 mM 0.0265 mL 0.1327 mL 0.2653 mL 0.6633 mL
60 mM 0.0221 mL 0.1106 mL 0.2211 mL 0.5528 mL
80 mM 0.0166 mL 0.0829 mL 0.1658 mL 0.4146 mL
100 mM 0.0133 mL 0.0663 mL 0.1327 mL 0.3317 mL
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SMART1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMART1SMART 1SMART-1PROTACsPDK-1Akt3-Phosphoinositide-dependent protein kinase 1PKBProtein kinase BPROTACSmurf1PDK1-Aktcolorectal cancerInhibitorinhibitorinhibit

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