2. PROTAC PI3K/Akt/mTOR
  3. PROTACs PDK-1 Akt
  4. SMART1

SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) .

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SMART1

SMART1 화학구조

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

SMART1 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) [1].
분자량

753.76

화학식

C40H35N9O7
Appearance

Solid

Color

Light yellow to green yellow

SMILES

CNC(C1=NC=CC(OC2=CC=C(C=C2)N3C=C(N=N3)C4=CC(NC(C5CCCN(C5)C6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CC=C4)=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 100 mg/mL (132.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3267 mL 6.6334 mL 13.2668 mL
5 mM 0.2653 mL 1.3267 mL 2.6534 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.87%

SDS (393 KB)

COA (244 KB) HNMR (466 KB) RP-HPLC (239 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3267 mL 6.6334 mL 13.2668 mL 33.1671 mL
5 mM 0.2653 mL 1.3267 mL 2.6534 mL 6.6334 mL
10 mM 0.1327 mL 0.6633 mL 1.3267 mL 3.3167 mL
15 mM 0.0884 mL 0.4422 mL 0.8845 mL 2.2111 mL
20 mM 0.0663 mL 0.3317 mL 0.6633 mL 1.6584 mL
25 mM 0.0531 mL 0.2653 mL 0.5307 mL 1.3267 mL
30 mM 0.0442 mL 0.2211 mL 0.4422 mL 1.1056 mL
40 mM 0.0332 mL 0.1658 mL 0.3317 mL 0.8292 mL
50 mM 0.0265 mL 0.1327 mL 0.2653 mL 0.6633 mL
60 mM 0.0221 mL 0.1106 mL 0.2211 mL 0.5528 mL
80 mM 0.0166 mL 0.0829 mL 0.1658 mL 0.4146 mL
100 mM 0.0133 mL 0.0663 mL 0.1327 mL 0.3317 mL
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SMART1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMART1SMART 1SMART-1PROTACsPDK-1Akt3-Phosphoinositide-dependent protein kinase 1PKBProtein kinase BPROTACSmurf1PDK1-Aktcolorectal cancerInhibitorinhibitorinhibit

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상품명:
SMART1
Cat. No.:
HY-W998345
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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