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YN14 mixture of diastereomers is the diastereomers of YN14 (HY-155356). YN14 is a KRASG12C proteolysis targeting chimera (PROTAC). YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth.

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YN14 (mixture of diastereomers)

YN14 (mixture of diastereomers) Chemische Struktur

CAS. Nr. : 3053689-54-3

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Beschreibung

YN14 mixture of diastereomers is the diastereomers of YN14 (HY-155356). YN14 is a KRASG12C proteolysis targeting chimera (PROTAC). YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth[1].

Molekulargewicht

1156.39

Formel

C62H75F2N11O7S
CAS. Nr.
SMILES

O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4F)OCC5CCN(CC5)CCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)=C(F)C=C3C(N9[C@H](CN(CC9)C(C=C)=O)C)=N1
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YN14 (mixture of diastereomers) Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

YN14 (mixture of diastereomers)3053689-54-3PROTACsKRASG12Cproteolysis targeting chimeraPROTACKRASG12C: YN14: VHLantiproliferativecancer cellTGIMIA PaCa-2 xenograftInhibitorinhibitorinhibit

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