YN14 (mixture of diastereomers)
YN14 mixture of diastereomers is a diastereomer mixture of YN14 (HY-155356). YN14 is a KRASG12C PROTAC degrader that recruits E3 ubiquitin ligase to induce the polyubiquitination and proteasomal degradation of KRASG12C. YN14 induces tumor cell apoptosis, cell cycle arrest, and cell migration inhibition. YN14 exhibits in vivo antitumor proliferative activity in tumor cell xenograft nude mice. YN14 can be used in cancer-related research.
(Pink: KRAS(G12C) ligand (HY-114277); Blue: VHL ligand (HY-125845); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3053689-54-3
- Formula: C62H75F2N11O7S
- Molecular Weight:1156.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
KRas G12C |
Caspase 3 |
Akt |
Chemical Information
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CAS No. 3053689-54-3
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Molecular Weight 1156.39
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Formula C62H75F2N11O7S
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SMILES
O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4F)OCC5CCN(CC5)CCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)=C(F)C=C3C(N9[C@H](CN(CC9)C(C=C)=O)C)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YN14 (mixture of diastereomers) Related Classifications
HY-155356A Related Classifications
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Keywords
- YN14 (mixture of diastereomers)
- 3053689-54-3
- PROTACs
- Ras
- PERK
- Akt
- Caspase
- E3 ubiquitin ligase
- non-small cell lung cancer cells
- proteasomal degradation
- tumor cell migration
- pancreatic cancer cells
- antitumor proliferation activity
- KRASG12C degrader
- tumor cell cycle arrest
- apoptosis
- KRASG12C polyubiquitination
- Inhibitor
- inhibitor
- inhibit