YN14 (mixture of diastereomers)

Cat. No.: HY-155356A: Ficha de datos Instrucciones de manejo
FAQs
Technical Support

YN14 mixture of diastereomers is the diastereomers of YN14 (HY-155356). YN14 is a KRASG12C proteolysis targeting chimera (PROTAC). YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth.

Para uso exclusivo en investigación. No vendemos a pacientes.

YN14 (mixture of diastereomers) Estructura química

No. CAS : 3053689-54-3

Tamaño		Stock
MOQ		Minimum order quantity
50 mg		Obtener un presupuesto
100 mg		Obtener un presupuesto
250 mg		Obtener un presupuesto
Other size		Obtener un presupuesto

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other Forms of YN14 (mixture of diastereomers):

YN14 In-stock

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PROTACs:

Ver todas las isoformas

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn	YN14 mixture of diastereomers is the diastereomers of YN14 (HY-155356). YN14 is a KRASG12C proteolysis targeting chimera (PROTAC). YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth^[1].
Peso molecular	1156.39
Fòrmula	C₆₂H₇₅F₂N₁₁O₇S
No. CAS	3053689-54-3
SMILES	O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4F)OCC5CCN(CC5)CCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)=C(F)C=C3C(N9[C@H](CN(CC9)C(C=C)=O)C)=N1
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (269 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Ning Yang, et al. Discovery of highly potent and selective KRASG12Cdegraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation. Eur J Med Chem. 2023 Dec 5:261:115857. [Content Brief]