3053689-54-3
Chemical Structure
YN14 (mixture of diastereomers)
- CAS No.: 3053689-54-3
- Formula:C62H75F2N11O7S
- Molecular Weight:1156.39
IUPAC Name: (2S,4R)-1-((2S)-2-(4-(4-((2-(4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-7-yl)-3-fluorophenoxy)methyl)piperidin-1-yl)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: LRCAYGWAXRSIDX-ZNRZZSIMSA-N
SMILES: O=C1N(C2=C(N=CC=C2C)C(C)C)C3=NC(C4=C(C=CC=C4F)OCC5CCN(CC5)CCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)=C(F)C=C3C(N9[C@H](CN(CC9)C(C=C)=O)C)=N1
Biological Activity: YN14 mixture of diastereomers is a diastereomer mixture of YN14 (HY-155356). YN14 is a KRASG12C PROTAC degrader that recruits E3 ubiquitin ligase to induce the polyubiquitination and proteasomal degradation of KRASG12C. YN14 induces tumor cell apoptosis, cell cycle arrest, and cell migration inhibition. YN14 exhibits in vivo antitumor proliferative activity in tumor cell xenograft nude mice. YN14 can be used in cancer-related research[1].
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YN14 (mixture of diastereomers) | YN14 mixture of diastereomers is a diastereomer mixture of YN14 (HY-155356). YN14 is a KRASG12C PROTAC degrader that recruits E3 ubiquitin ligase to induce the polyubiquitination and proteasomal degradation of KRASG12C. YN14 induces tumor cell apoptosis, cell cycle arrest, and cell migration inhibition. YN14 exhibits in vivo antitumor proliferative activity in tumor cell xenograft nude mice. YN14 can be used in cancer-related research. | |||||||||||||||||||||
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