pan-KRAS-IN-6
pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC50 values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V).
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- CAS. Nr.: 3033565-36-2
- Formel: C29H30ClF3N6O3S
- Molecular Weight:635.10
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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KRas G12D 9.79 nM (IC50) |
KRas G12V 6.03 nM (IC50) |
pan-KRAS-IN-6 (20 nM; 72 h) has a good inhibitory effect on the growth of ASPC-1 cells (IC50=8.8 μm)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AsPC-1 and SW480 cell lines
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Concentration:20 nM
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Incubation Time:72 h
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Result:Inhibited the growth of AsPC-1 cell lines
Chemical Information
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CAS. Nr. 3033565-36-2
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Molecular Weight 635.10
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Formel C29H30ClF3N6O3S
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SMILES
FC1=C(C2=C(N=C(N)S3)C3=C(F)C=C2)C(Cl)=CC4=C(N5CC(C)(O)COCC5)N=C(OC[C@@]6(CCC7)N7C[C@H](F)C6)N=C14
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
pan-KRAS-IN-6 Related Classifications
HY-162439 Related Classifications
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