PROTAC K-Ras Degrader-4
Based on 1 Customer Validation
PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway.
(Pink: ligand (HY-162960); Blue: Cereblon ligand (HY-W998248); Black: linker (HY-159790)).
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- Pureté : 99.01%
- CAS No.: 2938169-99-2
- Formule: C50H60N12O6S2
- Masse moléculaire:989.22
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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K-RAS |
In Vitro
PROTAC K-Ras Degrader-4 (0-1 μM, 5 days) inhibits the expression of DUSP6, and suppresses the proliferation of KRASG12D-mutated GP2d cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GP2d
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Concentration:0.1 nM-1 μM
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Incubation Time:5 days
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Result:Inhibited the proliferation of GP2d.
Chemical Information
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CAS No. 2938169-99-2
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Appearance Solid
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Masse moléculaire 989.22
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Formule C50H60N12O6S2
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Color White to light yellow
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SMILES
C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=C5)C)=NC=C3)=NO2)C9=C(CCC1)SC(N)=C9C#N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (101.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0109 mL | 5.0545 mL | 10.1090 mL | 25.2724 mL |
| 5 mM | 0.2022 mL | 1.0109 mL | 2.0218 mL | 5.0545 mL | |
| 10 mM | 0.1011 mL | 0.5054 mL | 1.0109 mL | 2.5272 mL | |
| 15 mM | 0.0674 mL | 0.3370 mL | 0.6739 mL | 1.6848 mL | |
| 20 mM | 0.0505 mL | 0.2527 mL | 0.5054 mL | 1.2636 mL | |
| 25 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL | 1.0109 mL | |
| 30 mM | 0.0337 mL | 0.1685 mL | 0.3370 mL | 0.8424 mL | |
| 40 mM | 0.0253 mL | 0.1264 mL | 0.2527 mL | 0.6318 mL | |
| 50 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5054 mL | |
| 60 mM | 0.0168 mL | 0.0842 mL | 0.1685 mL | 0.4212 mL | |
| 80 mM | 0.0126 mL | 0.0632 mL | 0.1264 mL | 0.3159 mL | |
| 100 mM | 0.0101 mL | 0.0505 mL | 0.1011 mL | 0.2527 mL |
PROTAC K-Ras Degrader-4 Related Classifications
HY-159788 Related Classifications
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