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Cat. No.: HY-159788

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PROTAC K-Ras Degrader-4

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Based on 1 Customer Validation

PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRAS^G12D in GP5d and degrades KRAS^G12V in cell SW620 with DC₅₀s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway.
(Pink: K-RAS ligand (HY-162960); Blue: Cereblon ligand (HY-W998248); Black: linker (HY-159790)).

For research use only. We do not sell to patients.

Purity: 99.01%
CAS No.: 2938169-99-2
Formula: C₅₀H₆₀N₁₂O₆S₂
Molecular Weight:989.22

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PROTAC K-Ras Degrader-4 Chemical Structure

CAS No.: 2938169-99-2

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRAS^G12D in GP5d and degrades KRAS^G12V in cell SW620 with DC₅₀s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway^[1]. (Pink: K-RAS ligand (HY-162960); Blue: Cereblon ligand (HY-W998248); Black: linker (HY-159790)).

IC₅₀ & Target

K-RAS

All PROTACs Isoforms :

All Ras Isoforms :

In Vitro

PROTAC K-Ras Degrader-4 (0-1 μM, 5 days) inhibits the expression of DUSP6, and suppresses the proliferation of KRAS^G12D-mutated GP2d cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

GP2d
Concentration:

0.1 nM-1 μM
Incubation Time:

5 days
Result:

Inhibited the proliferation of GP2d.

Chemical Information

CAS No. 2938169-99-2
Appearance Solid
Molecular Weight 989.22
Formula C₅₀H₆₀N₁₂O₆S₂
Color White to light yellow
SMILES

C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=C5)C)=NC=C3)=NO2)C9=C(CCC1)SC(N)=C9C#N
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (101.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0109 mL

5.0545 mL

10.1090 mL

5 mM

0.2022 mL

1.0109 mL

2.0218 mL

10 mM

0.1011 mL

0.5054 mL

1.0109 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385(6715):1338-1347. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0109 mL	5.0545 mL	10.1090 mL	25.2724 mL
	5 mM	0.2022 mL	1.0109 mL	2.0218 mL	5.0545 mL
	10 mM	0.1011 mL	0.5054 mL	1.0109 mL	2.5272 mL
	15 mM	0.0674 mL	0.3370 mL	0.6739 mL	1.6848 mL
	20 mM	0.0505 mL	0.2527 mL	0.5054 mL	1.2636 mL
	25 mM	0.0404 mL	0.2022 mL	0.4044 mL	1.0109 mL
	30 mM	0.0337 mL	0.1685 mL	0.3370 mL	0.8424 mL
	40 mM	0.0253 mL	0.1264 mL	0.2527 mL	0.6318 mL
	50 mM	0.0202 mL	0.1011 mL	0.2022 mL	0.5054 mL
	60 mM	0.0168 mL	0.0842 mL	0.1685 mL	0.4212 mL
	80 mM	0.0126 mL	0.0632 mL	0.1264 mL	0.3159 mL
	100 mM	0.0101 mL	0.0505 mL	0.1011 mL	0.2527 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
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MCE Japan Authorized Agent:

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PROTAC K-Ras Degrader-4

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

PROTAC Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

KRAS Targeted Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Anti-Cancer Compound Library

All PROTACs Isoforms

All Ras Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PROTAC K-Ras Degrader-4

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

PROTAC Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

KRAS Targeted Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Anti-Cancer Compound Library

All PROTACs Isoforms

All Ras Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PROTAC K-Ras Degrader-4 Related Classifications

HY-159788 Related Classifications