2938169-99-2
2938169-99-2
Chemical Structure
PROTAC K-Ras Degrader-4
- CAS No.: 2938169-99-2
- Formula:C50H60N12O6S2
- Molecular Weight:989.22
InChIKey: YIBGZBSCYLTBRE-GMDSDUMKSA-N
SMILES: C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=NOC([C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=C5)C)=NC=C3)=NO2)C9=C(CCC1)SC(N)=C9C#N
Biological Activity: PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC K-Ras Degrader-4 | 99.01% | PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.82
HY-157228ACBI3 -
Similarity Score 0.78
HY-186225KV-14 -
Similarity Score 0.74
HY-176792ACBI-4 -
Similarity Score 0.74
HY-176792A(R)-ACBI-4 -
Similarity Score 0.60
HY-180931PROTAC A515 -
Similarity Score 0.59
HY-169274PROTAC SMARCA2 degrader-23 -
Similarity Score 0.59
HY-153424PROTAC SMARCA2 degrader-1 -
Similarity Score 0.59
HY-168242PROTAC BRM/BRG1 degrader-1 -
Similarity Score 0.59
HY-155356AYN14 (mixture of diastereomers) -
Explore the MedChemAI to find more analogs
