2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs SWI/SNF Complex
  4. PROTAC A515

PROTAC A515 is a SMARCA2 PROTAC degrader. PROTAC A515 promotes the ubiquitination and degradation of SMARCA2. PROTAC A515 can be used in cancer research.

For research use only. We do not sell to patients.

PROTAC A515

PROTAC A515 Chemical Structure

CAS No. : 2378056-72-3

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PROTAC A515 Related Antibodies

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Description

PROTAC A515 is a SMARCA2 PROTAC degrader. PROTAC A515 promotes the ubiquitination and degradation of SMARCA2. PROTAC A515 can be used in cancer research[1].

IC50 & Target[1]

SMARCA2

 

Cellular Effect
Cell Line Type Value Description References
Calu-6 GI50
12 nM
Compound: 15
Antiproliferative activity against human Calu-6 cells assessed as growth inhibition incubated for 7 days by celltiter glo 2.0 assay
Antiproliferative activity against human Calu-6 cells assessed as growth inhibition incubated for 7 days by celltiter glo 2.0 assay
[PMID: 38180485]
Molecular Weight

1041.27

Formula

C55H68N12O7S
CAS No.
SMILES

CC1=C(SC=N1)C2=CC=C([C@H](C)NC([C@H]3N(C[C@@H](C3)O)C([C@@H](C4=CC(OCCN5C[C@H](N(CC5)CCOC6=NC=CC(N7C8CN(C9=C(N)N=NC(C%10=C(C=CC=C%10)O)=C9)CC7CC8)=C6)C)=NO4)C(C)C)=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC A515 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC A5152378056-72-3PROTAC A 515PROTAC A-515PROTACsSWI/SNF ComplexSWI/SNF Family of Chromatin-Remodelling ComplexesInhibitorinhibitorinhibit

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