PROTAC A515
PROTAC A515 is a SMARCA2 PROTAC degrader. PROTAC A515 promotes the ubiquitination and degradation of SMARCA2. PROTAC A515 can be used in cancer research.
(Pink: SMARCA2 ligand (HY-180932); Blue: VHL ligand (HY-168243); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2378056-72-3
- Formula: C55H68N12O7S
- Molecular Weight:1041.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-6 | GI50 |
12 nM
Compound: 15
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Antiproliferative activity against human Calu-6 cells assessed as growth inhibition incubated for 7 days by celltiter glo 2.0 assay
Antiproliferative activity against human Calu-6 cells assessed as growth inhibition incubated for 7 days by celltiter glo 2.0 assay
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[PMID: 38180485] |
Chemical Information
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CAS No. 2378056-72-3
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Molecular Weight 1041.27
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Formula C55H68N12O7S
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SMILES
CC1=C(SC=N1)C2=CC=C([C@H](C)NC([C@H]3N(C[C@@H](C3)O)C([C@@H](C4=CC(OCCN5C[C@H](N(CC5)CCOC6=NC=CC(N7C8CN(C9=C(N)N=NC(C%10=C(C=CC=C%10)O)=C9)CC7CC8)=C6)C)=NO4)C(C)C)=O)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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