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Cat. No.: HY-132920

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KRAS mutant protein inhibitor 1

KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential research in cancer.

For research use only. We do not sell to patients.

CAS No.: 2642630-16-6
Formula: C₃₁H₂₇Cl₃FN₇O₂
Molecular Weight:654.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KRAS mutant protein inhibitor 1 Chemical Structure

CAS No.: 2642630-16-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential research in cancer.

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H358	IC₅₀	14.49 nM Compound: 11B	Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay	[PMID: 34795848]
NCI-H358	IC₅₀	27.63 nM Compound: 11	Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay	[PMID: 34795848]

Chemical Information

CAS No. 2642630-16-6
Molecular Weight 654.95
Formula C₃₁H₂₇Cl₃FN₇O₂
SMILES

C=CC(N1CCN(CC1)C2=C(C(N(C3=NC(C4=C(C(Cl)=CC(Cl)=C4F)N)=C(C=C32)Cl)C5=C(C=CN=C5C(C)C)C)=O)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kargbo RB. Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in Cancer. ACS Med Chem Lett. 2021 Oct 7;12(11):1633-1634. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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KRAS mutant protein inhibitor 1

All Ras Isoforms