KRASG12D-IN-2
Based on 1 Customer Validation
KRASG12D-IN-2 (compound 28) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.
For research use only. We do not sell to patients.
- Purity: 98.11%
- Formula: C34H29D2F4N7O
- Molecular Weight:631.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1187 nM
Compound: 28
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Antiproliferative activity against human A549 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human A549 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| AGS | IC50 |
0.9 nM
Compound: 28
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Antiproliferative activity against human AGS cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human AGS cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| ASPC1 | IC50 |
1.6 nM
Compound: 28
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Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| NCI-H1299 | IC50 |
1849 nM
Compound: 28
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Antiproliferative activity against human NCI-H1299 cells harboring KRAS wild type assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human NCI-H1299 cells harboring KRAS wild type assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Appearance Solid
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Molecular Weight 631.66
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Formula C34H29D2F4N7O
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Color Light yellow to yellow
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SMILES
FC1=C(C2=CN=C1C3=C4C(C#C)=C(C=CC4=CC(N)=C3)F)N=C(N=C2N5C[C@H](CC6)N[C@H]6C5)OC([2H])([2H])C78CCCN7C/C(C8)=C(F)\F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (395.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5831 mL | 7.9157 mL | 15.8313 mL | 39.5783 mL |
| 5 mM | 0.3166 mL | 1.5831 mL | 3.1663 mL | 7.9157 mL | |
| 10 mM | 0.1583 mL | 0.7916 mL | 1.5831 mL | 3.9578 mL | |
| 15 mM | 0.1055 mL | 0.5277 mL | 1.0554 mL | 2.6386 mL | |
| 20 mM | 0.0792 mL | 0.3958 mL | 0.7916 mL | 1.9789 mL | |
| 25 mM | 0.0633 mL | 0.3166 mL | 0.6333 mL | 1.5831 mL | |
| 30 mM | 0.0528 mL | 0.2639 mL | 0.5277 mL | 1.3193 mL | |
| 40 mM | 0.0396 mL | 0.1979 mL | 0.3958 mL | 0.9895 mL | |
| 50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7916 mL | |
| 60 mM | 0.0264 mL | 0.1319 mL | 0.2639 mL | 0.6596 mL | |
| 80 mM | 0.0198 mL | 0.0989 mL | 0.1979 mL | 0.4947 mL | |
| 100 mM | 0.0158 mL | 0.0792 mL | 0.1583 mL | 0.3958 mL |
KRASG12D-IN-2 Related Classifications
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