2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRASG12D-IN-2

KRASG12D-IN-2 (compound 28) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.

For research use only. We do not sell to patients.

KRASG12D-IN-2 Chemical Structure

KRASG12D-IN-2 Chemical Structure

Size Price Stock Quantity
1 mg USD 450 In-stock
5 mg USD 980 In-stock
10 mg USD 1580 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

KRASG12D-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KRASG12D-IN-2 (compound 28) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition[1].

Molecular Weight

631.66

Formula

C34H29D2F4N7O
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=C(C2=CN=C1C3=C4C(C#C)=C(C=CC4=CC(N)=C3)F)N=C(N=C2N5C[C@H](CC6)N[C@H]6C5)OC([2H])([2H])C78CCCN7C/C(C8)=C(F)\F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (395.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5831 mL 7.9157 mL 15.8313 mL
5 mM 0.3166 mL 1.5831 mL 3.1663 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.11%

COA (258 KB) HNMR (279 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5831 mL 7.9157 mL 15.8313 mL 39.5783 mL
5 mM 0.3166 mL 1.5831 mL 3.1663 mL 7.9157 mL
10 mM 0.1583 mL 0.7916 mL 1.5831 mL 3.9578 mL
15 mM 0.1055 mL 0.5277 mL 1.0554 mL 2.6386 mL
20 mM 0.0792 mL 0.3958 mL 0.7916 mL 1.9789 mL
25 mM 0.0633 mL 0.3166 mL 0.6333 mL 1.5831 mL
30 mM 0.0528 mL 0.2639 mL 0.5277 mL 1.3193 mL
40 mM 0.0396 mL 0.1979 mL 0.3958 mL 0.9895 mL
50 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7916 mL
60 mM 0.0264 mL 0.1319 mL 0.2639 mL 0.6596 mL
80 mM 0.0198 mL 0.0989 mL 0.1979 mL 0.4947 mL
100 mM 0.0158 mL 0.0792 mL 0.1583 mL 0.3958 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KRASG12D-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRASG12D-IN-2RasKRASG12D-IN-1AsPC-1anti-tumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KRASG12D-IN-2
Cat. No.:
HY-157031S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.