KRASG12D-IN-2
Based on 1 Customer Validation
KRASG12D-IN-2 (compound 28) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.11%
- 分子式: C34H29D2F4N7O
- 分子量:631.66
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1187 nM
Compound: 28
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Antiproliferative activity against human A549 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human A549 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| AGS | IC50 |
0.9 nM
Compound: 28
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Antiproliferative activity against human AGS cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human AGS cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| ASPC1 | IC50 |
1.6 nM
Compound: 28
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Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
| NCI-H1299 | IC50 |
1849 nM
Compound: 28
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Antiproliferative activity against human NCI-H1299 cells harboring KRAS wild type assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
Antiproliferative activity against human NCI-H1299 cells harboring KRAS wild type assessed as inhibition of cell growth incubated for 5 days by crystal violet staining analysis
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[PMID: 37921024] |
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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性状 Solid
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分子量 631.66
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分子式 C34H29D2F4N7O
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Color Light yellow to yellow
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SMILES
FC1=C(C2=CN=C1C3=C4C(C#C)=C(C=CC4=CC(N)=C3)F)N=C(N=C2N5C[C@H](CC6)N[C@H]6C5)OC([2H])([2H])C78CCCN7C/C(C8)=C(F)\F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (395.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5831 mL | 7.9157 mL | 15.8313 mL | 39.5783 mL |
| 5 mM | 0.3166 mL | 1.5831 mL | 3.1663 mL | 7.9157 mL | |
| 10 mM | 0.1583 mL | 0.7916 mL | 1.5831 mL | 3.9578 mL | |
| 15 mM | 0.1055 mL | 0.5277 mL | 1.0554 mL | 2.6386 mL | |
| 20 mM | 0.0792 mL | 0.3958 mL | 0.7916 mL | 1.9789 mL | |
| 25 mM | 0.0633 mL | 0.3166 mL | 0.6333 mL | 1.5831 mL | |
| 30 mM | 0.0528 mL | 0.2639 mL | 0.5277 mL | 1.3193 mL | |
| 40 mM | 0.0396 mL | 0.1979 mL | 0.3958 mL | 0.9895 mL | |
| 50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7916 mL | |
| 60 mM | 0.0264 mL | 0.1319 mL | 0.2639 mL | 0.6596 mL | |
| 80 mM | 0.0198 mL | 0.0989 mL | 0.1979 mL | 0.4947 mL | |
| 100 mM | 0.0158 mL | 0.0792 mL | 0.1583 mL | 0.3958 mL |
KRASG12D-IN-2 関連分類
HY-157031S 関連分類
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