Cat. No.: HY-125847

Salvianolic acid F

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Salvianolic acid F is a KRAS inhibitor, especially for KRAS G12D. Salvianolic acid F inhibits NF-kB, MMP-9, and NO simultaneously. Salvianolic acid F inhibits cancer cell growth, invasion, and migration and induces apoptosis via the EP300/PI3K/AKT pathway in vitro. Salvianolic acid F inhibits the growth of KRAS-dependent lung cancer cells via the PI3K/AKT signaling pathway in vivo. Salvianolic acid F can be used in the research of various cancers, including KRAS G12D-driven non-small cell lung cancer (NSCLC) and ovarian cancer.

For research use only. We do not sell to patients.

Purity: 99.49%
CAS No.: 158732-59-3
Formula: C₁₇H₁₄O₆
Molecular Weight:314.29

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Salvianolic acid F Chemical Structure

CAS No.: 158732-59-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1][2]

K-RAS

Caspase 3

MMP-9

All Ras Isoforms :

All PI3K Isoforms :

All Akt Isoforms :

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

All NF-κB Isoforms :

All MMP Isoforms :

In Vitro

Salvianolic acid F (0-100 μM, 24-72 h) shows cytotoxicity against A549, OE-KRAS A549 cells, with 24 h IC₅₀s of 41.18, 36.55 μM, with 48 h IC₅₀s of 35.17, 29.33 μM, shows cytotoxicity against OVCAR-3, SK-OV-3 OC cells, with IC₅₀s of 28.89, 29.94 µM^[1][2].
Salvianolic acid F (0-40 μM, 48 h) inhibits migration and proliferation and promotes apoptosis in OE-KRAS A549, OVCAR-3, SK-OV-3 OC cells^[1][2].
Salvianolic acid F (0-40 μM, 48 h) suppresses the EP300/PI3K/AKT signaling pathway in OVCAR-3, SK-OV-3 OC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

OE-Ctrl, OE-KRAS, shCtrl, and shKRAS A549 cells
Concentration:

0, 10, 20 µM
Incubation Time:

48 h
Result:

Inhibited the in vitro migration of OE-KRAS A549 cells, but had a poorer inhibition on the migration of shKRAS A549 cells at 20 µM.

Apoptosis Analysis^[1]

Cell Line:

OE-KRAS and shKRAS A549 cells
Concentration:

0, 10, 20 µM
Incubation Time:

48 h
Result:

Induced marked apoptosis in OE-KRAS A549 cells, but showed not obvious apoptosis in shKRAS A549 cells.

Immunofluorescence^[2]

Cell Line:

OVCAR-3, SK-OV-3 OC cells
Concentration:

0, 20, 40 µM
Incubation Time:

48 h
Result:

Significant reduced EdU-positive cells.

Cell Migration Assay ^[2]

Cell Line:

OVCAR-3, SK-OV-3 OC cells
Concentration:

0, 20, 40 µM
Incubation Time:

48 h
Result:

Inhibited cell migration.

Apoptosis Analysis^[2]

Cell Line:

OVCAR-3, SK-OV-3 OC cells
Concentration:

0, 20, 40 µM
Incubation Time:

48 h
Result:

Exhibited a significantly elevated apoptosis rate in a dose-dependent manner compared to untreated cells.
Increased caspase-3 cleavage, Bax expression, decreased Bcl-2 expression in a dose-dependent manner compared to control cells.

Western Blot Analysis^[2]

Cell Line:

OVCAR-3, SK-OV-3 OC cells
Concentration:

0, 20, 40 µM
Incubation Time:

48 h
Result:

Decreased EP300, p-PI3K/PI3K, Bax/Bcl-2, and cleaved caspase-3/caspase-3 ratios.

In Vivo

Salvianolic acid F (10-20 mg/kg, i.p., each day for 15 days) is effective in inhibiting KRAS-driven lung tumor growth by influencing the downstream PI3K/AKT pathway in A549 xenografts nude mice model^[1].
Salvianolic acid F (10-20 mg/kg, i.p., every 2 days for 40 days) inhibits lung tumor growth by influencing the downstream PI3K/AKT pathway in Kras^G12D mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A549 (5 × 10⁶) xenografts nude mice (6 weeks old BALB/c) model^[1]
Dosage:

10, 20 mg/kg
Administration:

i.p., each day for 15 days
Result:

Did not induce significant weight loss and began to inhibit tumor growth from day 7 at 20 mg/kg, with no significant inhibitory effect at 10 mg/kg.
Inhibited the expression of KRAS and reduced cell proliferation in mice at 20 mg/kg.
Inhibited AKT phosphorylation, increased the expression of Bax, cleaved-Caspase3 and cleaved-PARP, decreased the expression of Bcl2, promoted apoptosis in lung cancer cells.

Animal Model:

Kras^G12D mice model^[1]
Dosage:

10, 20 mg/kg
Administration:

i.p., every 2 days for 40 days
Result:

Not changed body weight, decreased the number and size of lung tumors, reaching 48% and 64% in the 10 mg/kg and 20 mg/kg groups, compared with the control group.
Inhibited Kras^G12D expression, inhibited the pathological histomorphology, reduced cell proliferation.
Inhibited AKT phosphorylation, increased the expression of Bax, cleaved-Caspase3 and cleaved-PARP, decreased the expression of Bcl2, promoted apoptosis in lung cancer cells.

Chemical Information

CAS No. 158732-59-3
Appearance Solid
Molecular Weight 314.29
Formula C₁₇H₁₄O₆
Color Light yellow to yellow
SMILES

O=C(O)/C=C/C1=CC=C(O)C(O)=C1/C=C/C2=CC=C(O)C(O)=C2
Structure Classification
- Phenols
- Polyphenols
- Stilbenes
Initial Source
- Plants
- Labiatae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cancer Biother Radiopharm

Ultrasound-Enhanced Delivery of Salvianolic Acid F Targets CXCL5 to Suppress Lung Cancer Progression: Insights from In Vitro PC9 and H1299 Models. [Abstract]

2025 Sep 10. PMID: 40928959

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (318.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1818 mL

15.9089 mL

31.8177 mL

5 mM

0.6364 mL

3.1818 mL

6.3635 mL

10 mM

0.3182 mL

1.5909 mL

3.1818 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hou X, et al. Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway. Phytomedicine. 2023 Dec;121:155093. [Content Brief]

[2]. Ding C, et al. Preliminary exploration of the potential role of salvianolic acid F in regulating ovarian cancer cell proliferation, migration, invasion, and apoptosis and its association with the EP300/PI3K/AKT pathway. Adv Clin Exp Med. 2025 Apr 16. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1818 mL	15.9089 mL	31.8177 mL	79.5444 mL
	5 mM	0.6364 mL	3.1818 mL	6.3635 mL	15.9089 mL
	10 mM	0.3182 mL	1.5909 mL	3.1818 mL	7.9544 mL
	15 mM	0.2121 mL	1.0606 mL	2.1212 mL	5.3030 mL
	20 mM	0.1591 mL	0.7954 mL	1.5909 mL	3.9772 mL
	25 mM	0.1273 mL	0.6364 mL	1.2727 mL	3.1818 mL
	30 mM	0.1061 mL	0.5303 mL	1.0606 mL	2.6515 mL
	40 mM	0.0795 mL	0.3977 mL	0.7954 mL	1.9886 mL
	50 mM	0.0636 mL	0.3182 mL	0.6364 mL	1.5909 mL
	60 mM	0.0530 mL	0.2651 mL	0.5303 mL	1.3257 mL
	80 mM	0.0398 mL	0.1989 mL	0.3977 mL	0.9943 mL
	100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.7954 mL

Salvianolic acid F

1 Cited Publications

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Salvianolic acid F

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

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Publications Citing Use of MedChemExpress (MCE) Salvianolic acid F

All Ras Isoforms

All PI3K Isoforms

All Akt Isoforms

All Caspase Isoforms

All Bcl-2 Family Isoforms