Salvianolic acid F

Name: Salvianolic acid F
Brand: MedChemExpress
SKU: HY-125847
Rating: 4.5 (1 reviews)

製品番号: HY-125847 純度: 99.30%: Data Sheet SDS COA 取扱説明書
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Salvianolic acid F is a KRAS inhibitor, especially for KRAS G12D. Salvianolic acid F inhibits NF-kB, MMP-9, and NO simultaneously. Salvianolic acid F inhibits cancer cell growth, invasion, and migration and induces apoptosis via the EP300/PI3K/AKT pathway in vitro. Salvianolic acid F inhibits the growth of KRAS-dependent lung cancer cells via the PI3K/AKT signaling pathway in vivo. Salvianolic acid F can be used in the research of various cancers, including KRAS G12D-driven non-small cell lung cancer (NSCLC) and ovarian cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Salvianolic acid F 構造式

CAS 番号 : 158732-59-3

容量	価格（税別）	在庫状況	数量
1 mg	$120	在庫あり	Estimated Time of Arrival: December 31
5 mg	$300	在庫あり	Estimated Time of Arrival: December 31
10 mg	$450	在庫あり	Estimated Time of Arrival: December 31
25 mg	$810	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Cancer Biother Radiopharm. 2025 Sep 10. [Abstract]

Ras アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

K-Ras H-Ras N-Ras Ras

PI3K アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Akt Akt1 Akt2 Akt3

Caspase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Bcl-2 Family アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

MMP アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1][2]

K-RAS

Caspase 3

MMP-9

体外実験

Salvianolic acid F (0-100 μM, 24-72 h) shows cytotoxicity against A549, OE-KRAS A549 cells, with 24 h IC₅₀s of 41.18, 36.55 μM, with 48 h IC₅₀s of 35.17, 29.33 μM, shows cytotoxicity against OVCAR-3, SK-OV-3 OC cells, with IC₅₀s of 28.89, 29.94 µM^[1][2].
Salvianolic acid F (0-40 μM, 48 h) inhibits migration and proliferation and promotes apoptosis in OE-KRAS A549, OVCAR-3, SK-OV-3 OC cells^[1][2].
Salvianolic acid F (0-40 μM, 48 h) suppresses the EP300/PI3K/AKT signaling pathway in OVCAR-3, SK-OV-3 OC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:	OE-Ctrl, OE-KRAS, shCtrl, and shKRAS A549 cells
Concentration:	0, 10, 20 µM
Incubation Time:	48 h
Result:	Inhibited the in vitro migration of OE-KRAS A549 cells, but had a poorer inhibition on the migration of shKRAS A549 cells at 20 µM.

Apoptosis Analysis^[1]

Cell Line:	OE-KRAS and shKRAS A549 cells
Concentration:	0, 10, 20 µM
Incubation Time:	48 h
Result:	Induced marked apoptosis in OE-KRAS A549 cells, but showed not obvious apoptosis in shKRAS A549 cells.

Immunofluorescence^[2]

Cell Line:	OVCAR-3, SK-OV-3 OC cells
Concentration:	0, 20, 40 µM
Incubation Time:	48 h
Result:	Significant reduced EdU-positive cells.

Cell Migration Assay ^[2]

Cell Line:	OVCAR-3, SK-OV-3 OC cells
Concentration:	0, 20, 40 µM
Incubation Time:	48 h
Result:	Inhibited cell migration.

Apoptosis Analysis^[2]

Cell Line:	OVCAR-3, SK-OV-3 OC cells
Concentration:	0, 20, 40 µM
Incubation Time:	48 h
Result:	Exhibited a significantly elevated apoptosis rate in a dose-dependent manner compared to untreated cells. Increased caspase-3 cleavage, Bax expression, decreased Bcl-2 expression in a dose-dependent manner compared to control cells.

Western Blot Analysis^[2]

Cell Line:	OVCAR-3, SK-OV-3 OC cells
Concentration:	0, 20, 40 µM
Incubation Time:	48 h
Result:	Decreased EP300, p-PI3K/PI3K, Bax/Bcl-2, and cleaved caspase-3/caspase-3 ratios.

体内実験

Salvianolic acid F (10-20 mg/kg, i.p., each day for 15 days) is effective in inhibiting KRAS-driven lung tumor growth by influencing the downstream PI3K/AKT pathway in A549 xenografts nude mice model^[1].
Salvianolic acid F (10-20 mg/kg, i.p., every 2 days for 40 days) inhibits lung tumor growth by influencing the downstream PI3K/AKT pathway in Kras^G12D mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A549 (5 × 10⁶) xenografts nude mice (6 weeks old BALB/c) model^[1]
Dosage:	10, 20 mg/kg
Administration:	i.p., each day for 15 days
Result:	Did not induce significant weight loss and began to inhibit tumor growth from day 7 at 20 mg/kg, with no significant inhibitory effect at 10 mg/kg. Inhibited the expression of KRAS and reduced cell proliferation in mice at 20 mg/kg. Inhibited AKT phosphorylation, increased the expression of Bax, cleaved-Caspase3 and cleaved-PARP, decreased the expression of Bcl2, promoted apoptosis in lung cancer cells.

Animal Model:	Kras^G12D mice model^[1]
Dosage:	10, 20 mg/kg
Administration:	i.p., every 2 days for 40 days
Result:	Not changed body weight, decreased the number and size of lung tumors, reaching 48% and 64% in the 10 mg/kg and 20 mg/kg groups, compared with the control group. Inhibited Kras^G12D expression, inhibited the pathological histomorphology, reduced cell proliferation. Inhibited AKT phosphorylation, increased the expression of Bax, cleaved-Caspase3 and cleaved-PARP, decreased the expression of Bcl2, promoted apoptosis in lung cancer cells.

分子量

314.29

分子式

C₁₇H₁₄O₆

CAS 番号

158732-59-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)/C=C/C1=CC=C(O)C(O)=C1/C=C/C2=CC=C(O)C(O)=C2

Structure Classification

Stilbenes

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (318.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1818 mL	15.9089 mL	31.8177 mL
5 mM	0.6364 mL	3.1818 mL	6.3635 mL
10 mM	0.3182 mL	1.5909 mL	3.1818 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.50%

Select Batch:

データシート (283 KB) SDS (251 KB)

COA (250 KB) RP-HPLC (233 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Hou X, et al. Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway. Phytomedicine. 2023 Dec;121:155093. [Content Brief]

[2]. Ding C, et al. Preliminary exploration of the potential role of salvianolic acid F in regulating ovarian cancer cell proliferation, migration, invasion, and apoptosis and its association with the EP300/PI3K/AKT pathway. Adv Clin Exp Med. 2025 Apr 16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1818 mL	15.9089 mL	31.8177 mL	79.5444 mL
	5 mM	0.6364 mL	3.1818 mL	6.3635 mL	15.9089 mL
	10 mM	0.3182 mL	1.5909 mL	3.1818 mL	7.9544 mL
	15 mM	0.2121 mL	1.0606 mL	2.1212 mL	5.3030 mL
	20 mM	0.1591 mL	0.7954 mL	1.5909 mL	3.9772 mL
	25 mM	0.1273 mL	0.6364 mL	1.2727 mL	3.1818 mL
	30 mM	0.1061 mL	0.5303 mL	1.0606 mL	2.6515 mL
	40 mM	0.0795 mL	0.3977 mL	0.7954 mL	1.9886 mL
	50 mM	0.0636 mL	0.3182 mL	0.6364 mL	1.5909 mL
	60 mM	0.0530 mL	0.2651 mL	0.5303 mL	1.3257 mL
	80 mM	0.0398 mL	0.1989 mL	0.3977 mL	0.9943 mL
	100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.7954 mL