1. GPCR/G Protein
  2. Ras
  3. 6H05 (TFA)

6H05 (TFA) 

Cat. No.: HY-12408A Purity: 99.55%
Handling Instructions

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

For research use only. We do not sell to patients.

6H05 (TFA) Chemical Structure

6H05 (TFA) Chemical Structure

CAS No. : 2061344-88-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 217 In-stock
Estimated Time of Arrival: December 31
5 mg USD 167 In-stock
Estimated Time of Arrival: December 31
10 mg USD 294 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

Molecular Weight

590.14

Formula

C₂₂H₃₁ClF₃N₃O₄S₃

CAS No.

2061344-88-3

SMILES

O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 51 mg/mL (86.42 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6945 mL 8.4726 mL 16.9451 mL
5 mM 0.3389 mL 1.6945 mL 3.3890 mL
10 mM 0.1695 mL 0.8473 mL 1.6945 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

6H05 (TFA)RasInhibitorinhibitorinhibit

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6H05 (TFA)
Cat. No.:
HY-12408A
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