2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. 6H05 TFA

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

For research use only. We do not sell to patients.

6H05 TFA Chemical Structure

6H05 TFA Chemical Structure

CAS No. : 2061344-88-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 217 In-stock
Solution
10 mM * 1 mL in DMSO USD 217 In-stock
Solid
1 mg USD 79 In-stock
5 mg USD 167 In-stock
10 mg USD 294 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 6H05 TFA:

6H05 TFA Related Antibodies

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K-Ras H-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

Molecular Weight

590.14

Formula

C22H31ClF3N3O4S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (169.45 mM)

DMSO : ≥ 51 mg/mL (86.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6945 mL 8.4726 mL 16.9451 mL
5 mM 0.3389 mL 1.6945 mL 3.3890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.6945 mL 8.4726 mL 16.9451 mL 42.3628 mL
5 mM 0.3389 mL 1.6945 mL 3.3890 mL 8.4726 mL
10 mM 0.1695 mL 0.8473 mL 1.6945 mL 4.2363 mL
15 mM 0.1130 mL 0.5648 mL 1.1297 mL 2.8242 mL
20 mM 0.0847 mL 0.4236 mL 0.8473 mL 2.1181 mL
25 mM 0.0678 mL 0.3389 mL 0.6778 mL 1.6945 mL
30 mM 0.0565 mL 0.2824 mL 0.5648 mL 1.4121 mL
40 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0591 mL
50 mM 0.0339 mL 0.1695 mL 0.3389 mL 0.8473 mL
60 mM 0.0282 mL 0.1412 mL 0.2824 mL 0.7060 mL
80 mM 0.0212 mL 0.1059 mL 0.2118 mL 0.5295 mL
H2O 100 mM 0.0169 mL 0.0847 mL 0.1695 mL 0.4236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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6H05 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6H052061344-88-3RasInhibitorinhibitorinhibit

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