2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. 6H05

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (6H05 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

6H05 Chemical Structure

6H05 Chemical Structure

CAS No. : 1469338-01-9

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6H05 Related Antibodies

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K-Ras H-Ras Ras

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Description

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

IC50 & Target[1]

K-Ras(G12C)

 

Molecular Weight

476.12

Formula

C20H30ClN3O2S3
CAS No.
SMILES

O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6H05 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6H051469338-01-9RasInhibitorinhibitorinhibit

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