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Cat. No.: HY-178874

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E3 ligase Ligand 75

E3 ligase Ligand 75 is an E3 ligase ligand. E3 ligase Ligand 75 can be used for synthesis PROTAC K-Ras Degrader-7 (HY-178873).

For research use only. We do not sell to patients.

CAS No.: 3063924-16-0
Formula: C₃₃H₃₀F₃N₅O₄
Molecular Weight:617.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

E3 ligase Ligand 75 Chemical Structure

CAS No.: 3063924-16-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

E3 ligase Ligand 75 is an E3 ligase ligand. E3 ligase Ligand 75 can be used for synthesis PROTAC K-Ras Degrader-7 (HY-178873)^[1].

IC₅₀ & Target

VHL

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 3063924-16-0
Molecular Weight 617.62
Formula C₃₃H₃₀F₃N₅O₄
SMILES

FC1=C(C2=CC(O)=CC3=C2C(C#C)=C(F)C=C3)N=CC4=C1N=C(N=C4N5CCC(CC5)C(O)=O)OC[C@@]67N(CCC7)C[C@@H](C6)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Austin J, et al. PROTAC Compounds Binding Keap1 Ubiquitin Ligase for Targeted Protein Degradation. WO2025085815A1. 2025-04-24.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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E3 ligase Ligand 75

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 ligase Ligand 75 Related Classifications

HY-178874 Related Classifications