pan-KRAS-IN-10
pan-KRAS-IN-10 (Compound 58) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.7 and 0.24 nM, respectively.
For research use only. We do not sell to patients.
- Purity : 97.38%
- Formula: C45H57N7O5S
- Molecular Weight:808.04
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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Appearance Solid
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Molecular Weight 808.04
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Formula C45H57N7O5S
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Color White to off-white
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SMILES
CO[C@@H](C)C(N=C1)=[C@@]([C@@]2=C(CC(C)(C)COC3=O)C4=CC(C5=CSC(C[C@H](NC([C@H]6[C@H](C)[C@@H]6C)=O)C(N7CCC[C@@H]3N7)=O)=N5)=CC=C4N2CC)C=C1C#CCN(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (123.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2376 mL | 6.1878 mL | 12.3756 mL | 30.9391 mL |
| 5 mM | 0.2475 mL | 1.2376 mL | 2.4751 mL | 6.1878 mL | |
| 10 mM | 0.1238 mL | 0.6188 mL | 1.2376 mL | 3.0939 mL | |
| 15 mM | 0.0825 mL | 0.4125 mL | 0.8250 mL | 2.0626 mL | |
| 20 mM | 0.0619 mL | 0.3094 mL | 0.6188 mL | 1.5470 mL | |
| 25 mM | 0.0495 mL | 0.2475 mL | 0.4950 mL | 1.2376 mL | |
| 30 mM | 0.0413 mL | 0.2063 mL | 0.4125 mL | 1.0313 mL | |
| 40 mM | 0.0309 mL | 0.1547 mL | 0.3094 mL | 0.7735 mL | |
| 50 mM | 0.0248 mL | 0.1238 mL | 0.2475 mL | 0.6188 mL | |
| 60 mM | 0.0206 mL | 0.1031 mL | 0.2063 mL | 0.5157 mL | |
| 80 mM | 0.0155 mL | 0.0773 mL | 0.1547 mL | 0.3867 mL | |
| 100 mM | 0.0124 mL | 0.0619 mL | 0.1238 mL | 0.3094 mL |
pan-KRAS-IN-10 Related Classifications
HY-162443 Related Classifications
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