Fulzerasib
Based on 1 Customer Validation
Fulzerasib (GFH925) is an irreversible KRAS G12C inhibitor, has a synergistic anti-cancer effect with cetuximab (HY-P9905)..
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 2641747-54-6
- Formula: C32H30ClFN6O4
- Molecular Weight:617.07
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRAS(G12C) |
Fulzerasib covalently inhibits GDP/GTP nucleotide exchange on KRAS G12C (IC50: 29 nM), locking KRAS in its inactive GDP-bound state (RAS-GTP IC50: 74 nM), thereby blocking the KRAS signaling pathway (pERK IC50: 37 nM)[1].
Fulzerasib inhibits the growth of tumor cell lines carrying the KRAS G12C mutation (IC50: 2-20 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2641747-54-6
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Appearance Solid
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Molecular Weight 617.07
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Formula C32H30ClFN6O4
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Color Light yellow to yellow
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SMILES
O=C(C=C)N1CCN2C(C3=C(N4C5=C(C(C)C)N=CC=C5C)N=C(C6=C(O)C=CC=C6F)C(Cl)=C3)=C(N(C)C([C@@]2([H])C1)=O)C4=O
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Synonyms
IBI351; GFH925
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 116.67 mg/mL (189.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6206 mL | 8.1028 mL | 16.2056 mL | 40.5140 mL |
| 5 mM | 0.3241 mL | 1.6206 mL | 3.2411 mL | 8.1028 mL | |
| 10 mM | 0.1621 mL | 0.8103 mL | 1.6206 mL | 4.0514 mL | |
| 15 mM | 0.1080 mL | 0.5402 mL | 1.0804 mL | 2.7009 mL | |
| 20 mM | 0.0810 mL | 0.4051 mL | 0.8103 mL | 2.0257 mL | |
| 25 mM | 0.0648 mL | 0.3241 mL | 0.6482 mL | 1.6206 mL | |
| 30 mM | 0.0540 mL | 0.2701 mL | 0.5402 mL | 1.3505 mL | |
| 40 mM | 0.0405 mL | 0.2026 mL | 0.4051 mL | 1.0129 mL | |
| 50 mM | 0.0324 mL | 0.1621 mL | 0.3241 mL | 0.8103 mL | |
| 60 mM | 0.0270 mL | 0.1350 mL | 0.2701 mL | 0.6752 mL | |
| 80 mM | 0.0203 mL | 0.1013 mL | 0.2026 mL | 0.5064 mL | |
| 100 mM | 0.0162 mL | 0.0810 mL | 0.1621 mL | 0.4051 mL |
Fulzerasib Related Classifications
HY-152848 Related Classifications
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