RM-046
RM-046 is an orally active, selective ternary complex inhibitor of KRASQ61H (active form). RM-046 forms a ternary complex with cyclophilin A, binds to active KRASQ61H in a non-covalent manner, blocks effector binding via steric hindrance and inhibits downstream signal transduction. RM-046 inhibits ERK phosphorylation and cancer cell proliferation, and induces sustained RAS pathway signal inhibition, anti-tumor activity and tumor regression in preclinical xenograft models. RM-046 can be used for the research of KRASQ61H mutant cancers.
For research use only. We do not sell to patients.
- CAS No.: 3058972-05-4
- Formula: C62H79F3N8O9
- Molecular Weight:1137.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cyclophilin Isoforms
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Biological Activity
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KRas Q61H |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3058972-05-4
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Molecular Weight 1137.33
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Formula C62H79F3N8O9
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SMILES
O=C([C@H](C(C)C)N1C)N[C@H](C(N2CCC[C@@H]3N2)=O)CC4=CC(C5=CC6=C(C=C5)N(CC(F)(F)F)[C@]([C@]7=C([C@H](C)OC)N=CC(C8CCN(C9CC9)CC8)=C7)=C6CC(C)(C)COC3=O)=CC(OC[C@@H](N(C(C%10(C)COC%10)=O)CC%11)[C@@H]%11C1=O)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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