KRAS G12C degrader-1
KRAS G12C degrader-1 is a potent KRAS G12C degrader (DC50 < 100 nM). KRAS G12C degrader-1 is an HSP90-mediated CHAMP (chaperone-assisted protein degrader) that induces KRAS G12C degradation via a chaperone-mediated mechanism. KRAS G12C degrader-1 can be used in research related to non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2768099-51-8
- Formula: C63H75ClN14O6
- Molecular Weight:1159.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
KRAS G12C degrader-1 (compound 283) is a molecule composed of a KRAS G12C-binding moiety, an HSP90-binding moiety, and a middle linker chain, which significantly degrades KRAS G12C protein levels in LU65A cells (DC50 < 100 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2768099-51-8
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Molecular Weight 1159.81
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Formula C63H75ClN14O6
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SMILES
O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS G12C degrader-1 Related Classifications
HY-153881 Related Classifications
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