1. Metabolic Enzyme/Protease
    Apoptosis
    Anti-infection
  2. Farnesyl Transferase
    Apoptosis
    Influenza Virus
  3. FTI-277 hydrochloride

FTI-277 hydrochloride 

Cat. No.: HY-15872A Purity: >99.0%
Handling Instructions

FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibits hepatitis delta virus (HDV) infection.

For research use only. We do not sell to patients.

FTI-277 hydrochloride Chemical Structure

FTI-277 hydrochloride Chemical Structure

CAS No. : 180977-34-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 238 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
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100 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of FTI-277 hydrochloride:

Top Publications Citing Use of Products

    FTI-277 hydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150.

    MCF-7 cells are pretreated with the indicated chemical inhibitors for 30min, followed by 15 min treatment with RA (20 μM) + EPA (80 μM).Cell extracts are prepared and subjected to western blotting analysis.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibits hepatitis delta virus (HDV) infection.

    In Vitro

    Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner [3].

    In Vivo

    FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice [2].

    Molecular Weight

    484.07

    Formula

    C₂₂H₃₀ClN₃O₃S₂

    CAS No.

    180977-34-8

    SMILES

    CSCC[[email protected]@H](C(OC)=O)NC(C1=CC=C(NC[[email protected]@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (206.58 mM; Need ultrasonic)

    H2O : 50 mg/mL (103.29 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0658 mL 10.3291 mL 20.6582 mL
    5 mM 0.4132 mL 2.0658 mL 4.1316 mL
    10 mM 0.2066 mL 1.0329 mL 2.0658 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: >99.0%

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    Keywords:

    FTI-277FTI277FTI 277Farnesyl TransferaseApoptosisInfluenza VirusFtaseInhibitorinhibitorinhibit

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    Product name:
    FTI-277 hydrochloride
    Cat. No.:
    HY-15872A
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