1. Metabolic Enzyme/Protease
    Apoptosis
    GPCR/G Protein
  2. Farnesyl Transferase
    Apoptosis
    Ras
  3. FTI-277

FTI-277 

Cat. No.: HY-15872
Handling Instructions

FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

For research use only. We do not sell to patients.

FTI-277 Chemical Structure

FTI-277 Chemical Structure

CAS No. : 170006-73-2

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Top Publications Citing Use of Products

    FTI-277 purchased from MCE. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150.

    MCF-7 cells are pretreated with the indicated chemical inhibitors for 30min, followed by 15 min treatment with RA (20 μM) + EPA (80 μM).Cell extracts are prepared and subjected to western blotting analysis.

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    Description

    FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

    In Vitro

    Treatment with FTI-277 (20 μM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types[1]
    . Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    447.61

    Formula

    C₂₂H₂₉N₃O₃S₂

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Product Name:
    FTI-277
    Cat. No.:
    HY-15872
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