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Cat. No.: HY-170428

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IPS-06061

IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRAS^G12D-IPS06061, degrading KRAS^G12D with a DC₅₀ value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy.

For research use only. We do not sell to patients.

CAS No.: 3064065-83-1
Formula: C₂₁H₂₅NO₃
Molecular Weight:339.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IPS-06061 Chemical Structure

CAS No.: 3064065-83-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

KRas G12D

<500 nM (DC₅₀)

Cereblon

All Ras Isoforms :

All Ligands for E3 Ligase Isoforms :

In Vivo

IPS-06061 shows a strong anti-tumor efficacy using a xenograftanimal model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3064065-83-1
Molecular Weight 339.43
Formula C₂₁H₂₅NO₃
SMILES

O=C(OCC)[C@@H](N[C@H](C(C1=CC=CC=C1)=O)C)CCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kang I, et al. IPS-06061, a novel TPD molecular glue degrader targeting KRAS G12D[J]. Cancer Research, 2025, 85(8_Supplement_1): 384-384.

[2]. Xu YX, et al. A Comprehensive Review of Marketed KRAS Inhibitors and Degraders: Challenges and Opportunities. Med Res Rev. Published online February 9, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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IPS-06061

High-Throughput Bioactive Compound Library

All Ras Isoforms

All Ligands for E3 Ligase Isoforms