3064065-83-1
3064065-83-1
Chemical Structure
IPS-06061
- CAS No.: 3064065-83-1
- Formula:C21H25NO3
- Molecular Weight:339.43
InChIKey: IJFMWAXGMKJDEQ-LPHOPBHVSA-N
SMILES: O=C(OCC)[C@@H](N[C@H](C(C1=CC=CC=C1)=O)C)CCC2=CC=CC=C2
Biological Activity: IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRASG12D-IPS06061, degrading KRASG12D with a DC50 value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy[1][2].
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IPS-06061 | IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRASG12D-IPS06061, degrading KRASG12D with a DC50 value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy. | |||||||||||||||||||||
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References
- [1]. Kang I, et al. IPS-06061, a novel TPD molecular glue degrader targeting KRAS G12D[J]. Cancer Research, 2025, 85(8_Supplement_1): 384-384.
- [2]. Xu YX, et al. A Comprehensive Review of Marketed KRAS Inhibitors and Degraders: Challenges and Opportunities. Med Res Rev. Published online February 9, 2026. [Content Brief]
Keywords
