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Cat. No.: HY-170326

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HSP90-IN-35

Hsp90-in-35 is an inhibitor of Hsp90, with an IC₅₀ between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize KRAS G12C degrader-1 (PROTAC) (HY-153881).

For research use only. We do not sell to patients.

CAS No.: 1207597-54-3
Formula: C₂₇H₃₃N₅O₅
Molecular Weight:507.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

HSP90-IN-35 Chemical Structure

CAS No.: 1207597-54-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HSP90

0.05-0.5 μM (IC₅₀)

All HSP Isoforms :

In Vitro

HSP90-IN-35 (Compound 379) induces the degradation of the Hsp90 client protein Her2, with an IC₅₀ of 0.05-0.5 μM against Hsp90.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1207597-54-3
Molecular Weight 507.58
Formula C₂₇H₃₃N₅O₅
SMILES

O=C(O)C1CCN(CC2=CC=C(N3C(C(NCC)=O)=NN=C3C4=C(O)C=C(O)C(C(C)C)=C4)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. DAVIS, et al. Preparation of substituted triazoles, particularly 4,5-diphenyl-4H-1,2,4-triazole-3-carboxamides, that modulate Hsp90 activity. WO2010017545 A2.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HSP90-IN-35

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HSP90-IN-35 Related Classifications

HY-170326 Related Classifications