SML-8-73-1
SML-8-73-1 is a nucleotide-based KRASG12C inhibitor. SML-8-73-1 can be used for the study of non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 1536470-92-4
- Formula: C14H21ClN6O12P2
- Molecular Weight:562.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRAS(G12C) |
SML-8-73-1 (2.5 μM, 2 h) can specifically and covalently modify KRASG12C, but not KRASWT[1].
SML-8-73-1 (2.5 μM, 2 h) can effectively bind to KRASG12C at high intracellular nucleotide concentrations, overcoming competitive inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1536470-92-4
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Molecular Weight 562.75
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Formula C14H21ClN6O12P2
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SMILES
O=C1C(N=CN2[C@@H]3O[C@H](COP(OP(OCCNC(CCl)=O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)=C2N=C(N)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lim SM, et al. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. [Content Brief]
[2]. Huang L, Guo Z, Wang F, Fu L. KRAS mutation: from undruggable to druggable in cancer. Signal Transduct Target Ther. 2021 Nov 15;6(1):386. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SML-8-73-1 Related Classifications
HY-19315 Related Classifications
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