KRAS-IN-48 free base
KRAS-IN-48 free base (Compound 1-01) is a mutant KRAS inhibitor, with Kd values of 2.58 nM and 5.49 μM for KRAS G12D and KRAS G12V, respectively. KRAS-IN-48 free base affects pERK expression in cells harboring KRAS G12D and KRAS G12V mutations, with IC50 values of 1.1 μM and 1.51 μM, respectively. KRAS-IN-48 free base can be used in the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 3074833-86-3
- Formula: C35H37F2N7O3
- Molecular Weight:641.71
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
KRas G12D 2.58 nM (Kd) |
KRas G12V 5.49 μM (Kd) |
Chemical Information
-
CAS No. 3074833-86-3
-
Molecular Weight 641.71
-
Formula C35H37F2N7O3
-
SMILES
F[C@H](C1)CN(CCC2)[C@]12COC3=NC(N4CC5NC(CC5)C4)=C6N(C7CCC7)C(OC8=CC(O)=CC9=C8C(C#C)=C(F)C=C9)=NC6=N3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS-IN-48 free base Related Classifications
HY-179300 Related Classifications
Powered by Bioz