1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Deltasonamide 1

Deltasonamide 1 

Cat. No.: HY-122641
Handling Instructions

Deltasonamide 1 is a PDE6δ-KRas inhibitor, with a KD of 203 pM.

For research use only. We do not sell to patients.

Deltasonamide 1 Chemical Structure

Deltasonamide 1 Chemical Structure

CAS No. : 2088485-33-8

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Deltasonamide 1 is a PDE6δ-KRas inhibitor, with a KD of 203 pM[1].

In Vitro

Deltasonamide 1 binds inside the PDE6δ binding pocket, including H-bonds to R61, Q78, E88, and Y149 sidechains, to the carbonyl of C56, two water molecule-mediated H-bonds to the Glu 88 side-chain and the amide proton of M118, two aromatic–p interactions to the indole side-chains of W32 and W90, and one M117-aryl interaction[1].
Deltasonamide 1 migrates slowly but show enhanced apparent permeability from the B to A side suggesting a potential interaction with efflux transporters. Deltasonamides results in a reduced interacting fraction of RheB-PDE6δ[1].
Deltasonamide 1 results in a strongly reduced proliferation, even at submicromolar concentrations in MiaPaCa-2 cells[1].

Cell Proliferation Assay[1]

Cell Line: RTCA of hPDAC cell lines.
Concentration: 0.375, 0.75, 1.5, 3, 6, 12 μM.
Incubation Time: 60 h.
Result: Inhibited proliferation of human pancreatic cancer cell lines.
Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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Deltasonamide 1Deltasonamide1Deltasonamide-1Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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