1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Deltasonamide 1

Deltasonamide 1 

Cat. No.: HY-122641
Handling Instructions

Deltasonamide 1 is a PDE6δ-KRas inhibitor, with a KD of 203 pM.

For research use only. We do not sell to patients.

Deltasonamide 1 Chemical Structure

Deltasonamide 1 Chemical Structure

CAS No. : 2088485-33-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Deltasonamide 1:

Other Forms of Deltasonamide 1:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Deltasonamide 1 is a PDE6δ-KRas inhibitor, with a KD of 203 pM[1].

In Vitro

Deltasonamide 1 binds inside the PDE6δ binding pocket, including H-bonds to R61, Q78, E88, and Y149 sidechains, to the carbonyl of C56, two water molecule-mediated H-bonds to the Glu 88 side-chain and the amide proton of M118, two aromatic–p interactions to the indole side-chains of W32 and W90, and one M117-aryl interaction[1].
Deltasonamide 1 migrates slowly but show enhanced apparent permeability from the B to A side suggesting a potential interaction with efflux transporters. Deltasonamides results in a reduced interacting fraction of RheB-PDE6δ[1].
Deltasonamide 1 results in a strongly reduced proliferation, even at submicromolar concentrations in MiaPaCa-2 cells[1].

Cell Proliferation Assay[1]

Cell Line: RTCA of hPDAC cell lines.
Concentration: 0.375, 0.75, 1.5, 3, 6, 12 μM.
Incubation Time: 60 h.
Result: Inhibited proliferation of human pancreatic cancer cell lines.
Molecular Weight

647.25

Formula

C₃₀H₃₉ClN₆O₄S₂

CAS No.

2088485-33-8

SMILES

O=S(C1=CC=C(S(=O)(N(CC2=NC(NC)=NC=C2)CC3CCNCC3)=O)C=C1)(N(CC4=CC=C(Cl)C=C4)C5CCCC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Deltasonamide 1Deltasonamide1Deltasonamide-1Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Deltasonamide 1
Cat. No.:
HY-122641
Quantity:
MCE Japan Authorized Agent: