Deltasonamide 1 TFA
Based on 1 Customer Validation
Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors.
For research use only. We do not sell to patients.
- CAS No.: 2235358-73-1
- Formula: C32H40ClF3N6O6S2
- Molecular Weight:761.27
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
KD: 203 pM (PDE6δ-KRas)[1]
Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM[1].
Deltasonamide 1 binds to PDE6δ with up to 7 hydrogen bonds, resulting in picomolar affinity[1].
Deltasonamide 1 strongly reduces proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RTCA of hPDAC cell lines
-
Concentration:0.375, 0.75, 1.5, 3, 6, 12 μM
-
Incubation Time:60 h
-
Result:Inhibited proliferation of human pancreatic cancer cell lines.
Chemical Information
-
CAS No. 2235358-73-1
-
Appearance Solid
-
Molecular Weight 761.27
-
Formula C32H40ClF3N6O6S2
-
Color White to off-white
-
SMILES
O=S(C1=CC=C(S(=O)(N(CC2=NC(NC)=NC=C2)CC3CCNCC3)=O)C=C1)(N(CC4=CC=C(Cl)C=C4)C5CCCC5)=O.O=C(O)C(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 200 mg/mL (262.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3136 mL | 6.5680 mL | 13.1359 mL | 32.8399 mL |
| 5 mM | 0.2627 mL | 1.3136 mL | 2.6272 mL | 6.5680 mL | |
| 10 mM | 0.1314 mL | 0.6568 mL | 1.3136 mL | 3.2840 mL | |
| 15 mM | 0.0876 mL | 0.4379 mL | 0.8757 mL | 2.1893 mL | |
| 20 mM | 0.0657 mL | 0.3284 mL | 0.6568 mL | 1.6420 mL | |
| 25 mM | 0.0525 mL | 0.2627 mL | 0.5254 mL | 1.3136 mL | |
| 30 mM | 0.0438 mL | 0.2189 mL | 0.4379 mL | 1.0947 mL | |
| 40 mM | 0.0328 mL | 0.1642 mL | 0.3284 mL | 0.8210 mL | |
| 50 mM | 0.0263 mL | 0.1314 mL | 0.2627 mL | 0.6568 mL | |
| 60 mM | 0.0219 mL | 0.1095 mL | 0.2189 mL | 0.5473 mL | |
| 80 mM | 0.0164 mL | 0.0821 mL | 0.1642 mL | 0.4105 mL | |
| 100 mM | 0.0131 mL | 0.0657 mL | 0.1314 mL | 0.3284 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz