1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Deltasonamide 1 TFA

Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors.

For research use only. We do not sell to patients.

Deltasonamide 1 TFA Chemical Structure

Deltasonamide 1 TFA Chemical Structure

CAS No. : 2235358-73-1

Size Price Stock Quantity
1 mg USD 260 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2580 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors[1].

IC50 & Target

KD: 203 pM (PDE6δ-KRas)[1]

In Vitro

Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM[1].
Deltasonamide 1 binds to PDE6δ with up to 7 hydrogen bonds, resulting in picomolar affinity[1].
Deltasonamide 1 strongly reduces proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: RTCA of hPDAC cell lines
Concentration: 0.375, 0.75, 1.5, 3, 6, 12 μM
Incubation Time: 60 h
Result: Inhibited proliferation of human pancreatic cancer cell lines.
Molecular Weight

761.27

Formula

C32H40ClF3N6O6S2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(S(=O)(N(CC2=NC(NC)=NC=C2)CC3CCNCC3)=O)C=C1)(N(CC4=CC=C(Cl)C=C4)C5CCCC5)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 200 mg/mL (262.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3136 mL 6.5680 mL 13.1359 mL
5 mM 0.2627 mL 1.3136 mL 2.6272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3136 mL 6.5680 mL 13.1359 mL 32.8399 mL
5 mM 0.2627 mL 1.3136 mL 2.6272 mL 6.5680 mL
10 mM 0.1314 mL 0.6568 mL 1.3136 mL 3.2840 mL
15 mM 0.0876 mL 0.4379 mL 0.8757 mL 2.1893 mL
20 mM 0.0657 mL 0.3284 mL 0.6568 mL 1.6420 mL
25 mM 0.0525 mL 0.2627 mL 0.5254 mL 1.3136 mL
30 mM 0.0438 mL 0.2189 mL 0.4379 mL 1.0947 mL
40 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8210 mL
50 mM 0.0263 mL 0.1314 mL 0.2627 mL 0.6568 mL
60 mM 0.0219 mL 0.1095 mL 0.2189 mL 0.5473 mL
80 mM 0.0164 mL 0.0821 mL 0.1642 mL 0.4105 mL
100 mM 0.0131 mL 0.0657 mL 0.1314 mL 0.3284 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Deltasonamide 1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Deltasonamide 1 TFA
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HY-122641D
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