2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. LUNA18

LUNA18 is an orally active KRAS inhibitor with an IC50 of <2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

LUNA18 Chemical Structure

LUNA18 Chemical Structure

CAS No. : 2676177-63-0

Size Price Stock Quantity
1 mg USD 1450 In-stock
5 mg USD 3980 In-stock
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

LUNA18 is an orally active KRAS inhibitor with an IC50 of <2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer[1].

IC50 & Target

IC50: <2 nM (KRASG12D-SOS)[1]
0.043 nM (KRASG12D)[1]
Molecular Weight

1437.68

Formula

C73H105F5N12O12
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (69.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6956 mL 3.4778 mL 6.9557 mL
5 mM 0.1391 mL 0.6956 mL 1.3911 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.26%

COA (262 KB) RP-HPLC (366 KB) LCMS (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6956 mL 3.4778 mL 6.9557 mL 17.3891 mL
5 mM 0.1391 mL 0.6956 mL 1.3911 mL 3.4778 mL
10 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.7389 mL
15 mM 0.0464 mL 0.2319 mL 0.4637 mL 1.1593 mL
20 mM 0.0348 mL 0.1739 mL 0.3478 mL 0.8695 mL
25 mM 0.0278 mL 0.1391 mL 0.2782 mL 0.6956 mL
30 mM 0.0232 mL 0.1159 mL 0.2319 mL 0.5796 mL
40 mM 0.0174 mL 0.0869 mL 0.1739 mL 0.4347 mL
50 mM 0.0139 mL 0.0696 mL 0.1391 mL 0.3478 mL
60 mM 0.0116 mL 0.0580 mL 0.1159 mL 0.2898 mL
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LUNA18 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LUNA182676177-63-0LUNA 18LUNA-18RasLS180GSUNCI-H441NCI-H2122MiaPaCa-2Inhibitorinhibitorinhibit

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