1. GPCR/G Protein
  2. Ras

KRAS G12C inhibitor 5 

Cat. No.: HY-114168
Handling Instructions

KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 5 Chemical Structure

KRAS G12C inhibitor 5 Chemical Structure

CAS No. : 2158297-63-1

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  • Biological Activity

  • Technical Information

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  • References

Description

KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147[1].

IC50 & Target

KRas G12C[1]

In Vitro

Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8126 mL 9.0632 mL 18.1265 mL
5 mM 0.3625 mL 1.8126 mL 3.6253 mL
10 mM 0.1813 mL 0.9063 mL 1.8126 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

551.68

Formula

C₃₂H₃₇N₇O₂

CAS No.

2158297-63-1

SMILES

N#CC[[email protected]@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[[email protected]]6N(C)CCC6)=N2)C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
KRAS G12C inhibitor 5
Cat. No.:
HY-114168
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KRAS G12C inhibitor 5

Cat. No.: HY-114168