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Cat. No.: HY-176419

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KRAS inhibitor-42

KRAS inhibitor-42 (compound 8) is a potent USP7 inhibitor. KRAS inhibitor-42 has high affinity against GDP-bound KRASG12D with a K_i of 2.7 μM.

For research use only. We do not sell to patients.

Formula: C₃₄H₄₇ClN₈O₄S₂
Molecular Weight:731.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

KRAS inhibitor-42 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

KRAS inhibitor-42 (compound 8) is a potent USP7 inhibitor. KRAS inhibitor-42 has high affinity against GDP-bound KRASG12D with a K_i of 2.7 μM^[1].

All Ras Isoforms :

Chemical Information

Molecular Weight 731.37
Formula C₃₄H₄₇ClN₈O₄S₂
SMILES

OC1=C2C(S/C(N2CCCCCN([C@H]3CC[C@@H](N)CC3)C4=O)=N\S(C5=CN=C(N6CCC(N7CCC(N)CC7)CC6)C4=C5)(=O)=O)=C(Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Waterson AG. Switching It up with New KRAS Inhibitors. J Med Chem. 2025 May 8;68(9):9126-9128. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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