5-Iodoindolin-2-one
Based on 1 Customer Validation
5-Iodoindolin-2-one (5-iodo-2,3-dihydro-1H-indol-2-one) is an intermediate that can be used in the synthesis of degraders, such as KRAS degrader-1 (HY-153880).
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 193354-13-1
- Formula: C8H6INO
- Molecular Weight:259.05
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5-Iodoindolin-2-one (Compound a) is an intermediate that can be used in the synthesis of degraders[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 193354-13-1
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Appearance Solid
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Molecular Weight 259.05
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Formula C8H6INO
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Color Brown to reddish brown
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SMILES
O=C1NC2=CC=C(I)C=C2C1
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Synonyms
5-iodo-2,3-dihydro-1H-indol-2-one
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (386.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8603 mL | 19.3013 mL | 38.6026 mL | 96.5065 mL |
| 5 mM | 0.7721 mL | 3.8603 mL | 7.7205 mL | 19.3013 mL | |
| 10 mM | 0.3860 mL | 1.9301 mL | 3.8603 mL | 9.6506 mL | |
| 15 mM | 0.2574 mL | 1.2868 mL | 2.5735 mL | 6.4338 mL | |
| 20 mM | 0.1930 mL | 0.9651 mL | 1.9301 mL | 4.8253 mL | |
| 25 mM | 0.1544 mL | 0.7721 mL | 1.5441 mL | 3.8603 mL | |
| 30 mM | 0.1287 mL | 0.6434 mL | 1.2868 mL | 3.2169 mL | |
| 40 mM | 0.0965 mL | 0.4825 mL | 0.9651 mL | 2.4127 mL | |
| 50 mM | 0.0772 mL | 0.3860 mL | 0.7721 mL | 1.9301 mL | |
| 60 mM | 0.0643 mL | 0.3217 mL | 0.6434 mL | 1.6084 mL | |
| 80 mM | 0.0483 mL | 0.2413 mL | 0.4825 mL | 1.2063 mL | |
| 100 mM | 0.0386 mL | 0.1930 mL | 0.3860 mL | 0.9651 mL |
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