5-Iodoindolin-2-one (Synonyms: 5-iodo-2,3-dihydro-1H-indol-2-one)

Cat. No.: HY-76986 Purity: 99.25%: Data Sheet
COA

SDS
Handling Instructions
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5-Iodoindolin-2-one (5-iodo-2,3-dihydro-1H-indol-2-one) is an intermediate that can be used in the synthesis of degraders, such as KRAS degrader-1 (HY-153880).

For research use only. We do not sell to patients.

5-Iodoindolin-2-one Chemical Structure

CAS No. : 193354-13-1

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Free Sample (0.1 - 0.2 mg)	Apply Now
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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Description

5-Iodoindolin-2-one (5-iodo-2,3-dihydro-1H-indol-2-one) is an intermediate that can be used in the synthesis of degraders, such as KRAS degrader-1 (HY-153880)^[1].

In Vitro

5-Iodoindolin-2-one (Compound a) is an intermediate that can be used in the synthesis of degraders^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

259.05

Formula

C₈H₆INO

CAS No.

193354-13-1

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1NC2=CC=C(I)C=C2C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (386.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8603 mL	19.3013 mL	38.6026 mL
5 mM	0.7721 mL	3.8603 mL	7.7205 mL
10 mM	0.3860 mL	1.9301 mL	3.8603 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (286 KB) SDS (394 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Wei Xiaofeng, et al. A selective mTORC1 degrader based on the autophagy-lysosome pathway and its preparation method and application. CN119462690A. 2026-02-06

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8603 mL	19.3013 mL	38.6026 mL	96.5065 mL
	5 mM	0.7721 mL	3.8603 mL	7.7205 mL	19.3013 mL
	10 mM	0.3860 mL	1.9301 mL	3.8603 mL	9.6506 mL
	15 mM	0.2574 mL	1.2868 mL	2.5735 mL	6.4338 mL
	20 mM	0.1930 mL	0.9651 mL	1.9301 mL	4.8253 mL
	25 mM	0.1544 mL	0.7721 mL	1.5441 mL	3.8603 mL
	30 mM	0.1287 mL	0.6434 mL	1.2868 mL	3.2169 mL
	40 mM	0.0965 mL	0.4825 mL	0.9651 mL	2.4127 mL
	50 mM	0.0772 mL	0.3860 mL	0.7721 mL	1.9301 mL
	60 mM	0.0643 mL	0.3217 mL	0.6434 mL	1.6084 mL
	80 mM	0.0483 mL	0.2413 mL	0.4825 mL	1.2063 mL
	100 mM	0.0386 mL	0.1930 mL	0.3860 mL	0.9651 mL

5-Iodoindolin-2-one Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Iodoindolin-2-one193354-13-15-iodo-2,3-dihydro-1H-indol-2-oneDrug IntermediateDrug IintermediateInhibitorinhibitorinhibit

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5-Iodoindolin-2-one (Synonyms: 5-iodo-2,3-dihydro-1H-indol-2-one)

5-Iodoindolin-2-one Related Antibodies

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