pan-KRAS-IN-2
Based on 1 Customer Validation
pan-KRAS-IN-2 (Compound 6) is a pan-inhibitor with IC50s ≤ 10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A and Q61H); and an IC50 > 10 μM for KRAS G13D. pan-KRAS-IN-2 can be used to study various KRAS-mediated cancers, such as pancreatic cancer and colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2882825-14-9
- Formula: C34H34F2N4O3
- Molecular Weight:584.66
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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GPCR/G Protein Compound Library
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Immunology/Inflammation Compound Library
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Kinase Inhibitor Library
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MAPK Compound Library
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Anti-Cancer Compound Library
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Oxygen Sensing Compound Library
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Ferroptosis Compound Library
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Glutamine Metabolism Compound Library
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Anti-Lung Cancer Compound Library
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Anti-Pancreatic Cancer Compound Library
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Anti-Blood Cancer Compound Library
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Angiogenesis-Related Compound Library
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Anti-Liver Cancer Compound Library
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Anti-Colorectal Cancer Compound Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Anti-Hematopathy Compound Library
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Multi-Target Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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Lactylation Compound Library
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Alkyne Compound Library
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KRAS Targeted Compound Library
HY-L260
Biological Activity
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K-Ras WT ≤ 10 nM (IC50) |
KRas G12D ≤ 10 nM (IC50) |
KRas G12C ≤ 10 nM (IC50) |
KRas G12V ≤ 10 nM (IC50) |
KRas G12S ≤ 10 nM (IC50) |
KRas Q61H ≤ 10 nM (IC50) |
KRAS G13D > 10 μM (IC50) |
Chemical Information
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CAS No. 2882825-14-9
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Appearance Solid
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Molecular Weight 584.66
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Formula C34H34F2N4O3
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Color White to off-white
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SMILES
CC1=C(C2=CC(O)=CC3=C2C(C#C)=C(F)C=C3)C=CC4=C1N=C(N=C4N5CCCOCC5)OC[C@@]67N(CCC7)C[C@@H](C6)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (213.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7104 mL | 8.5520 mL | 17.1040 mL | 42.7599 mL |
| 5 mM | 0.3421 mL | 1.7104 mL | 3.4208 mL | 8.5520 mL | |
| 10 mM | 0.1710 mL | 0.8552 mL | 1.7104 mL | 4.2760 mL | |
| 15 mM | 0.1140 mL | 0.5701 mL | 1.1403 mL | 2.8507 mL | |
| 20 mM | 0.0855 mL | 0.4276 mL | 0.8552 mL | 2.1380 mL | |
| 25 mM | 0.0684 mL | 0.3421 mL | 0.6842 mL | 1.7104 mL | |
| 30 mM | 0.0570 mL | 0.2851 mL | 0.5701 mL | 1.4253 mL | |
| 40 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0690 mL | |
| 50 mM | 0.0342 mL | 0.1710 mL | 0.3421 mL | 0.8552 mL | |
| 60 mM | 0.0285 mL | 0.1425 mL | 0.2851 mL | 0.7127 mL | |
| 80 mM | 0.0214 mL | 0.1069 mL | 0.2138 mL | 0.5345 mL | |
| 100 mM | 0.0171 mL | 0.0855 mL | 0.1710 mL | 0.4276 mL |
pan-KRAS-IN-2 Related Classifications
HY-156529 Related Classifications
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