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Cat. No.: HY-149607

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SHP2-IN-22

SHP2-IN-22 is SHP2 allosteric inhibitor with an IC₅₀ value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research.

For research use only. We do not sell to patients.

CAS No.: 2802453-88-7
Formula: C₂₃H₂₂Cl₂N₈O
Molecular Weight:497.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SHP2-IN-22 Chemical Structure

CAS No.: 2802453-88-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
KYSE-520 cell line	IC₅₀	1.8 μM Compound: 23	Antiproliferative activity against human KYSE-520 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-LumiII Luminescent assay Antiproliferative activity against human KYSE-520 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-LumiII Luminescent assay	[PMID: 37754066]
MIA PaCa-2	IC₅₀	6.8 μM Compound: 23	Antiproliferative activity against human MIA PaCa-2 cells harboring KRASG12C mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-LumiII Luminescent assay Antiproliferative activity against human MIA PaCa-2 cells harboring KRASG12C mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-LumiII Luminescent assay	[PMID: 37754066]

Chemical Information

CAS No. 2802453-88-7
Molecular Weight 497.38
Formula C₂₃H₂₂Cl₂N₈O
SMILES

N/C(N1CCN(CC1)C2=CN=C(C(N)=N2)C3=CC=CC(Cl)=C3Cl)=N\C4=CC(OC)=C(C=C4)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hou Q, et al. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers. J Med Chem. 2023 Oct 12;66(19):13646-13664. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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