KRAS inhibitor-20
KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM.
For research use only. We do not sell to patients.
- CAS No.: 2411786-32-6
- Formula: C31H40F4N6O2
- Molecular Weight:604.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
KRAS(G12C) <10 nM (IC50, [1]) |
In Vitro
KRAS inhibitor-20 (compound 12b) results KRasG12C alkylation human lung cancer adenocarcinoma (HCC 1171) with an EC50 value of 3.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2411786-32-6
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Molecular Weight 604.68
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Formula C31H40F4N6O2
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SMILES
C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=C(F)C(N)=CC(C)=C5C(F)(F)F)C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS inhibitor-20 Related Classifications
HY-151287 Related Classifications
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